description
In addition to the more prevalent point mutations, BRAF and RAF1 are also subject to activation as a result of translocation events that yield truncated or fusion products (Jones et al, 2008; Cin et al, 2011; Palanisamy et al, 2010; Ciampi et al, 2005; Stransky et al, 2014; Hutchinson et al, 2013; Zhang et al, 2013; Lee et al, 2012; Ricarte-Filho et al, 2013; reviewed in Lavoie and Therrien et al, 2015). In general these events put the C-terminal kinase domain of BRAF or RAF1 downstream of an N-terminal sequence provided by a partner protein. This removes the N-terminal region of the RAF protein, relieving the autoinhibition imposed by this region of the protein. In addition, some but not all of the fusion partner proteins have been shown to contain coiled-coil or other dimerization domains. Taken together, the fusion proteins are thought to dimerize constitutively and activate downstream signaling (Jones et al, 2008; Lee et al, 2012; Hutchinson et al, 2013; Ciampi et al, 2005; Cin et al, 2011; Stransky et al, 2014)

external resources
NCBI:1457786
REACTOME:R-HSA-6802952
PUBMED:18974108
PUBMED:24135138
PUBMED:22745804
PUBMED:25907612
PUBMED:20526349
PUBMED:15630448
PUBMED:25204415
PUBMED:24345920
PUBMED:21424530
PUBMED:23583981

genes
ARAF , ARRB1 , ARRB2 , BRAF , CLCN6 , CSK , FGA , FGB , FGG , FN1 , HRAS , ITGA2B , ITGB3 , JAK2 , KRAS , LMNA , MARK3 , NRAS , PEBP1 , MAPK1 , MAPK3 , MAP2K1 , MAP2K2 , RAF1 , RAP1A , RAP1B , SRC , TLN1 , VCL , VWF , YWHAB , FXR1 , AP3B1 , TRIM24 , IQGAP1 , KSR1 , PAPSS1 , QKI , FAM131B , BCL2L11 , AKAP9 , CNKSR1 , ATG7 , FAM114A2 , TENT4A , CNKSR2 , TRAK1 , MPRIP , MACF1 , SND1 , APBB1IP , ESRP1 , AGGF1 , AGK , ZC3HAV1 , AGTRAP , KIAA1549 , KDM7A , KSR2 , KIAA0754 ,