description
Under conditions of cellular stress, nuclear levels of phosphatidylinositol-5-phosphate (PI5P) increase and, through interaction with ING2, result in nuclear retention/accumulation of ING2. ING2 binds TP53 (p53) and recruits histone acetyltransferase EP300 (p300) to TP53, leading to TP53 acetylation. Increased nuclear PI5P levels positively regulate TP53 acetylation (Ciruela et al. 2000, Gozani et al. 2003, Jones et al. 2006, Zou et al. 2007, Bultsma et al. 2010)

external resources
NCBI:1457792
REACTOME:R-HSA-6811555
PUBMED:10698683
PUBMED:12859901
PUBMED:20583997
PUBMED:16949365
PUBMED:17940011

genes
EP300 , ING2 , PIN1 , PIP4K2A , MAP2K6 , TP53 , PIP4K2B , PIP4K2C , PIP4P1 , MIR1281 ,