description
Signaling by ERBB2 can be downregulated by ubiquitination and subsequent proteasome-dependent degradation of ERBB2 or activated ERBB2 heterodimers. In addition, protein tyrosine phosphatases that dephosphorylate tyrosine residues in the C-terminus of ERBB2 prevent the recruitment of adapter proteins involved in signal transduction, thus attenuating ERBB2 signaling.STUB1 (CHIP) and CUL5 are E3 ubiquitin ligases that can target non-activated ERBB2 for proteasome-dependent degradation (Xu et al. 2002, Ehrlich et al. 2009). RNF41 (NRDP1) is an E3 ubiquitin ligase that targets ERBB3 and activated heterodimers of ERBB2 and ERBB3 for proteasome-dependent degradation by ubiquitinating ERBB3 (Cao et al. 2007).Two protein tyrosine phosphatases of the PEST family, PTPN12 and PTPN18, dephosphorylate tyrosine residues in the C-terminus of ERBB2, thus preventing signal transduction to RAS and PI3K effectors (Sun et al. 2011, Wang et al. 2014)

external resources
NCBI:1457793
REACTOME:R-HSA-8863795
PUBMED:19933325
PUBMED:21376233
PUBMED:17210635
PUBMED:12239347
PUBMED:25081058

genes
AKT1 , AKT2 , BTC , HBEGF , EGF , EGFR , ERBB2 , ERBB3 , ERBB4 , EREG , NRG1 , HSP90AA1 , MATK , PTPN12 , RPS27A , UBA52 , UBB , UBC , CUL5 , USP8 , NRG2 , AKT3 , RNF41 , STUB1 , NRG3 , CDC37 , PTPN18 , ERBIN , NRG4 , MIR1181 ,