description
MET receptor activates the focal adhesion kinase PTK2 (FAK1) in a process that depends on the simultaneous interaction of PTK2 with integrins and with MET. SRC is needed for PTK2 to become fully active. Activation of PTK2 is needed for HGF-induced cell motility (Beviglia et al. 1999, Parr et al. 2001, Chen and Chen 2006, Lietha et al. 2007, Chen et al. 2011, Brami-Cherrier et al. 2014)

external resources
NCBI:1457800
REACTOME:R-HSA-8874081
PUBMED:17574028
PUBMED:24480479
PUBMED:11478803
PUBMED:16782899
PUBMED:10521801
PUBMED:20802513

genes
HGF , ITGA2 , ITGA3 , ITGB1 , LAMA2 , LAMA3 , LAMA4 , LAMA5 , LAMB1 , LAMB2 , LAMB3 , LAMC1 , LAMC2 , MET , PTK2 , SRC , LAMC3 , LAMA1 , MIR4260 , MIR4758 ,