description
The adapter protein GAB1 is involved in recruitment, through CRK and related CRKL proteins, of guanyl nucleotide exchange factors (GEFs) to the activated MET receptor. MET-associated GEFs, such as RAPGEF1 (C3G) and DOCK7, activate RAP1 and RAC1, respectively, leading to morphological changes that contribute to cell motility (Schaeper et al. 2000, Sakkab et al. 2000, Lamorte et al. 2002, Watanabe et al. 2006, Murray et al. 2014)

external resources
NCBI:1457802
REACTOME:R-HSA-8875555
PUBMED:10753869
PUBMED:12006644
PUBMED:16849525
PUBMED:10871282
PUBMED:24518591

genes
CRK , CRKL , GAB1 , GRB2 , RAPGEF1 , HGF , MET , RAC1 , RAP1A , RAP1B , DOCK7 ,