description
Immunity to different classes of microorganisms is orchestrated by separate lineages of effector T helper (TH)-cells, which differentiate from naive CD4+ precursor cells in response to cues provided by antigen presenting cells (APC) and include T helper type 1 (Th1) and Th2. Th1 cells are characterized by the transcription factor T-bet and signal transducer and activator of transcription (STAT) 4, and the production of IFN-gamma. These cells stimulate strong cell-mediated immune responses, particularly against intracellular pathogens. On the other hand, transcription factors like GATA-3 and STAT6 drive the generation of Th2 cells that produce IL-4, IL-5 and IL-13 and are necessary for inducing the humoral response to combat parasitic helminths (type 2 immunity) and isotype switching to IgG1 and IgE. The balance between Th1/Th2 subsets determines the susceptibility to disease states, where the improper development of Th2 cells can lead to allergy, while an overactive Th1 response can lead to autoimmunity

external resources
NCBI:1458885
KEGG:hsa04658
PUBMED:15819694
PUBMED:12171942
PUBMED:19165228
PUBMED:23336087
PUBMED:26044597
PUBMED:19151746
PUBMED:19362457
PUBMED:22044277
PUBMED:11752608
PUBMED:23405903
PUBMED:19375293
PUBMED:24113868
PUBMED:19151747
PUBMED:23624818
PUBMED:22566933
PUBMED:11121747
PUBMED:20969597
PUBMED:20065998

genes
JAG1 , RUNX3 , CD3D , CD3E , CD3G , CD247 , CD4 , CHUK , MAPK14 , FOS , GATA3 , HLA-DMA , HLA-DMB , HLA-DOA , HLA-DOB , HLA-DPA1 , HLA-DPB1 , HLA-DQA1 , HLA-DQA2 , HLA-DQB1 , HLA-DRA , HLA-DRB1 , HLA-DRB5 , IFNG , IFNGR1 , IFNGR2 , RBPJ , IKBKB , IL2 , IL2RA , IL2RB , IL2RG , IL4 , IL4R , IL5 , IL12A , IL12B , IL12RB1 , IL12RB2 , IL13 , JAG2 , JAK1 , JAK2 , JAK3 , JUN , LCK , MAF , NFATC1 , NFATC2 , NFATC3 , NFKB1 , NFKBIA , NFKBIB , NFKBIE , NOTCH1 , NOTCH2 , NOTCH3 , PLCG1 , PPP3CA , PPP3CB , PPP3CC , PPP3R1 , PPP3R2 , PRKCQ , MAPK1 , MAPK3 , MAPK8 , MAPK11 , MAPK9 , MAPK10 , MAPK13 , RELA , MAPK12 , STAT1 , STAT4 , STAT5A , STAT5B , STAT6 , TYK2 , ZAP70 , IKBKG , MAML1 , DLL3 , RBPJL , LAT , DLL1 , TBX21 , DLL4 , MAML3 , MAML2 ,