description
The C-propeptides of collagen propeptide chains are essential for the association of three peptide chains into a trimeric but non-helical procollagen. This initial binding event determines the composition of the trimer, brings the individual chains into the correct register and initiates formation of the triple helix at the C-terminus, which then proceeds towards the N-terminus in a zipper-like fashion (Engel & Prockop 1991). Most early refolding studies were performed with collagen type III, which contains a disulfide linkage at the C-terminus of its triple helix (B?chinger et al. 1978, Bruckner et al. 1978) that acts as a permanent linker even after removal of the non-collagenous domains. Mutations within the C-propeptides further suggest that they are crucial for the correct interaction of the three polypeptide chains and for subsequent correct folding (refs. in Boudko et al. 2011)

external resources
NCBI:1470926
REACTOME:R-HSA-8948216
PUBMED:710450
PUBMED:171650

genes
COL1A1 , COL1A2 , COL2A1 , COL3A1 , COL4A1 , COL4A2 , COL4A3 , COL4A4 , COL4A5 , COL4A6 , COL5A1 , COL5A2 , COL6A1 , COL6A2 , COL6A3 , COL7A1 , COL8A1 , COL8A2 , COL9A1 , COL9A2 , COL9A3 , COL10A1 , COL11A1 , COL11A2 , COL12A1 , COL13A1 , COL15A1 , COL16A1 , COL17A1 , COL19A1 , COL14A1 , COL5A3 , COL20A1 , COL18A1 , COL21A1 , COL25A1 , COL27A1 , COL23A1 , COL6A6 , COL26A1 , COL22A1 , COL24A1 , COL6A5 , COL28A1 , MIR936 , MIR711 , MIR3606 ,