description
The interleukin 17 (IL-17) family, a subset of cytokines consisting of IL-17A-F, plays crucial roles in both acute and chronic inflammatory responses. IL-17A, the hallmark cytokine of the newly defined T helper 17 (TH17) cell subset, has important roles in protecting the host against extracellular pathogens, but also promotes inflammatory pathology in autoimmune disease, whereas IL-17F is mainly involved in mucosal host defense mechanisms. IL-17E (IL-25) is an amplifier of Th2 immune responses. IL-17C has biological functions similar to those of IL-17A. The functions of IL-17B and IL-17D remain largely elusive. The IL-17 family signals via their correspondent receptors and activates downstream pathways that include NF-kappaB, MAPKs and C/EBPs to induce the expression of antimicrobial peptides, cytokines and chemokines. The receptor proximal adaptor Act1 (an NF-kappaB activator 1) is considered as the master mediator in IL-17A signaling. It is likely that Act1 is a common signal adaptor also shared by other members mediated signalings in this family

external resources
NCBI:1474301
KEGG:hsa04657
PUBMED:17921324
PUBMED:24011563
PUBMED:21349428
PUBMED:20383173
PUBMED:20514051
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PUBMED:25145755
PUBMED:17177681
PUBMED:19575028
PUBMED:23557798
PUBMED:21852080
PUBMED:22324470

genes
CASP3 , CASP8 , CEBPB , CHUK , MAPK14 , CSF2 , CSF3 , DEFB4A , ELAVL1 , FOS , FOSB , CXCL1 , CXCL2 , CXCL3 , GSK3B , HSP90AA1 , HSP90AB1 , IFNG , IKBKB , IL1B , IL4 , IL5 , IL6 , CXCL8 , IL13 , IL17A , CXCL10 , JUN , JUND , LCN2 , MMP1 , MMP3 , MMP9 , MMP13 , NFKB1 , NFKBIA , MAPK1 , MAPK3 , MAPK4 , MAPK6 , MAPK7 , MAPK8 , MAPK11 , MAPK9 , MAPK10 , MAPK13 , PTGS2 , RELA , S100A7 , S100A8 , S100A9 , MAPK12 , CCL2 , CCL7 , CCL11 , CCL17 , CCL20 , CXCL6 , CXCL5 , SRSF1 , MAP3K7 , TNF , TNFAIP3 , HSP90B1 , TRAF2 , TRAF3 , TRAF5 , TRAF6 , FOSL1 , IKBKG , TRADD , FADD , TRAF4 , IKBKE , TRAF3IP2 , TAB2 , IL17RA , IL17C , IL17B , TBK1 , USP25 , ANAPC5 , IL17D , IL17RB , IL25 , IL17RC , IL17F , IL17RE , MAPK15 , TAB3 , MUC5B , DEFB4B ,