description
Apelin is an endogenous peptide capable of binding the apelin receptor (APJ), which was originally described as an orphan G-protein-coupled receptor. Apelin and APJ are widely expressed in various tissues and organ systems. They are implicated in different key physiological processes such as angiogenesis, cardiovascular functions, cell proliferation and energy metabolism regulation. On the other hand, this ligand receptor couple is also involved in several pathologies including diabetes, obesity, cardiovascular disease and cancer

external resources
NCBI:1492886
KEGG:hsa04371
PUBMED:23973488
PUBMED:16182514
PUBMED:21725702
PUBMED:22842084
PUBMED:27825851
PUBMED:27650065
PUBMED:22140623
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PUBMED:26944568
PUBMED:24055369
PUBMED:26385179
PUBMED:26143239
PUBMED:22028387
PUBMED:26254105
PUBMED:26756969
PUBMED:22995518
PUBMED:27979574
PUBMED:23924696
PUBMED:21464822
PUBMED:25914650
PUBMED:24990699
PUBMED:26607438
PUBMED:25164121
PUBMED:25275559
PUBMED:25139773
PUBMED:25931124
PUBMED:19093215
PUBMED:20539939
PUBMED:25652330
PUBMED:18272138
PUBMED:23603510

genes
ACTA2 , ADCY1 , ADCY2 , ADCY3 , ADCY5 , ADCY6 , ADCY7 , ADCY8 , ADCY9 , JAG1 , AGTR1 , APLNR , AKT1 , AKT2 , CCND1 , CALM1 , CALM2 , CALM3 , CALML3 , CAMK4 , CDH1 , CTGF , EGR1 , MTOR , GNAI1 , GNAI2 , GNAI3 , GNAQ , GNB1 , GNB2 , GNB3 , GNG3 , GNG4 , GNG5 , GNG7 , GNG10 , GNG11 , GNGT1 , GNGT2 , HRAS , ITPR1 , ITPR2 , ITPR3 , JAG2 , KRAS , LIPE , SMAD2 , SMAD3 , SMAD4 , MEF2A , BORCS8-MEF2B , MEF2C , MEF2D , MYL2 , MYL3 , MYL4 , MYLK , NOS1 , NOS2 , NOS3 , NOTCH3 , NRAS , NRF1 , SERPINE1 , PDE3B , PIK3C3 , PIK3CG , PLAT , PLCB2 , PLCB3 , PLCB4 , PLIN1 , PRKAA1 , PRKAA2 , PRKAB1 , PRKAB2 , PRKACA , PRKACB , PRKACG , PRKAG1 , PRKCE , MAPK1 , MAPK3 , MAP2K1 , MAP2K2 , RAF1 , RPS6 , RPS6KB1 , RPS6KB2 , RRAS , RYR1 , RYR2 , RYR3 , SLC8A2 , SLC8A1 , SLC8A3 , SLC9A1 , SPP1 , TFAM , TGFBR1 , UCP1 , BECN1 , APLN , SPHK1 , HDAC4 , AKT3 , HDAC5 , KLF2 , GNA13 , GNB5 , PPARGC1A , GABARAP , GABARAPL2 , RRAS2 , MRAS , PLCB1 , PIK3R5 , GABARAPL1 , PIK3R4 , PRKAG2 , GNG13 , CALML5 , PRKAG3 , GNG2 , ADCY10 , GNG12 , SPHK2 , GNB4 , MYLK2 , MYLK3 , CALML4 , GNG8 , PIK3R6 , CALML6 , ADCY4 , MYLK4 , BECN2 , MEF2B ,