description
: GDP-MANNOSE is a key substrate in glycoprotein formation. In humans, :MANNOSE is a key monosaccharide for the glycosylation of proteins and lipids. Mannose-containing glycoconjugates, such as protein N- and C-glycans, some O-glycans, glycosylphosphatidylinositol (GPI) protein membrane anchors, and some glycolipids, have a variety of important functions. These functions include the promotion of correct folding, solubility, stability and intracellular sorting of proteins, promoting the enzymatic, hormonal or receptor activity of many proteins, and the formation of cell surface glycocalyces and extracellular matrices. In addition, glycoproteins are known to play major roles in cell-cell interactions (see : MANNOSYL-CHITO-DOLICHOL-BIOSYNTHESIS). : GDP-MANNOSE is the critical metabolite of the mannose activation pathway for glycoconjugate synthesis in humans, as it is utilized directly or indirectly as a mannose donor for all mannosylation reactions. In addition, : GDP-MANNOSE is a precursor for the biosynthesis of several important compounds, including : GUANOSINE_DIPHOSPHATE_FUCOSE (see : PWY-66)

external resources
NCBI:142196
BIOCYC:HUMAN_PWY-5659

genes
MPI , PMM1 , PMM2 , GMPPA ,