description
General Background : PRO is not an essential amino acid, as it can be synthesized in the body from : GLT, see : PROSYN-PWY. Proline is important for protein synthesis, and as a source of glutamate can be a precursor for : PWY66-398 intermediates. It also participates in a metabolic cycle that shuttles redox equivalents between the mitochondria and cytosol . However, high : PRO levels are detrimental to health and can cause seizures and mental retardation. About this Pathway : PRO is catabolized to : GLT by the action of two enzymes, : HS01958-MONOMER (proline oxidase) and : CPLX-6746 in the mitochondrion . The product of : HS01958-MONOMER, : L-DELTA1-PYRROLINE_5-CARBOXYLATE is in spontaneous equilibrium with its open form : L-GLUTAMATE_GAMMA-SEMIALDEHYDE . : L-GLUTAMATE_GAMMA-SEMIALDEHYDE is then irreversibly oxidized by : CPLX-6746 to form : GLT

external resources
NCBI:142377
BIOCYC:HUMAN_PROUT-PWY
PUBMED:22516612
PUBMED:15662599
PUBMED:8621661
PUBMED:18287100

genes
ALDH4A1 ,