description
In the kidney, the antidiuretic hormone vasopressin (AVP) is a critical regulator of water homeostasis by controlling the water movement from lumen to the interstitium for water reabsorption and adjusting the urinary water excretion. In normal physiology, AVP is secreted into the circulation by the posterior pituitary gland, in response to an increase in serum osmolality or a decrease in effective circulating volume. When reaching the kidney, AVP binds to V2 receptors on the basolateral surface of the collecting duct epithelium, triggering a G-protein-linked signaling cascade, which leads to water channel aquaporin-2 (AQP2) vesicle insertion into the apical plasma membrane. This results in higher water permeability in the collecting duct and, driven by an osmotic gradient, pro-urinary water then passes the membrane through AQP2 and leaves the cell on the basolateral side via AQP3 and AQP4 water channels, which are constitutively expressed on the basolateral side of these cells. When isotonicity is restored, reduced blood AVP levels results in AQP2 internalization, leaving the apical membrane watertight again

external resources
NCBI:143700
KEGG:hsa04962
PUBMED:14586738
PUBMED:17956998
PUBMED:11001488
PUBMED:10073616
PUBMED:18566824
PUBMED:18431594
PUBMED:11773613
PUBMED:18655910
PUBMED:10070156
PUBMED:15522987
PUBMED:10099706

genes
ADCY3 , ADCY6 , ADCY9 , AQP2 , AQP3 , AQP4 , ARHGDIA , ARHGDIB , ARHGDIG , AVP , AVPR2 , CREB1 , DCTN1 , DYNC1H1 , DYNC1I1 , DYNC1I2 , DYNC1LI2 , GNAS , NSF , PRKACA , PRKACB , PRKACG , RAB5A , RAB5B , RAB5C , STX4 , VAMP2 , DYNLL1 , RAB11A , RAB11B , CREB5 , CREB3 , DCTN2 , DCTN6 , DYNC1LI1 , DCTN4 , DYNC2LI1 , CREB3L2 , DYNC2H1 , DCTN5 , CREB3L3 , CREB3L1 , DYNLL2 , CREB3L4 ,