description
Cell surface proteins can be attached to the cell membrane via the glycolipid structure called glycosylphosphatidylinositol (GPI) anchor. Hundreds of GPI-anchored proteins have been identified in many eukaryotes ranging from protozoa and fungi to mammals. All protein-linked GPI anchors share a common core structure, characterized by the substructure Man (a1-4) GlcN (a1-6) myo-inositol-1P-lipid. Biosynthesis of GPI anchors proceeds in three stages: (i) preassembly of a GPI precursor in the ER membrane, (ii) attachment of the GPI to the C-terminus of a newly synthesized protein in the lumen of the ER, and (iii) lipid remodeling and/or carbohydrate side-chain modifications in the ER and the Golgi. Defects of GPI anchor biosynthesis gene result in a genetic disorder, paroxysmal nocturnal hemoglobinuria

external resources
NCBI:82988
KEGG:hsa00563
PUBMED:8253761
PUBMED:14517336
PUBMED:10329735
PUBMED:12655644
PUBMED:15635094
PUBMED:14734546
PUBMED:11102867
PUBMED:12802054
PUBMED:12807000
PUBMED:15623507

genes
GPLD1 , PIGA , PIGC , PIGF , PIGH , GPAA1 , DPM2 , PIGQ , PIGL , PIGB , PIGK , PIGN , PIGP , PIGT , PIGG , PIGX , PIGV , PGAP1 , PIGZ , PIGO , PIGY , PIGM , PIGS , PIGU , PIGW ,