description
One of the important roles of the collecting duct segment of the kidney nephron is acid secretion. As daily food intake loads acid into the body, urinary acid excretion is essential, and urine pH can drop as low as 4.5. The alpha-intercalated cell of collecting duct is the main responsible for hydrogen secretion into the urine. The carbon dioxide, which is generated in the cells and enters from the blood, is changed to carbonic acid. This carbonic acid is divided into hydrogen ion and bicarbonate ion. Intracellular CA II catalyses the formation of these ions. The hydrogen ion is secreted into the lumen by the luminal H(+)-ATPase. The bicarbonate ion is transported to the blood side by the anion exchanger type 1. Hydrogen ion in the lumen is trapped by urinary buffers. These include ammonium and phosphate

external resources
NCBI:147586
KEGG:hsa04966
PUBMED:11045400
PUBMED:19948674
PUBMED:16352913
PUBMED:11826292
PUBMED:19721811
PUBMED:17557941
PUBMED:9550618
PUBMED:19277700

genes
ATP4A , ATP4B , ATP6V1A , ATP6V1B1 , ATP6V1B2 , ATP6V0C , ATP6V1C1 , ATP6V1E1 , ATP6V1G2 , ATP6V0A1 , CA2 , CLCNKB , SLC4A1 , ATP6V0E1 , ATP6V0D1 , ATP6V1F , ATP6V1G1 , TCIRG1 , SLC12A7 , ATP6V0A2 , ATP6V0A4 , ATP6V1D , ATP6V1E2 , ATP6V1G3 , ATP6V0E2 , ATP6V0D2 , ATP6V1C2 ,