description
Trypanosoma cruzi is an intracellular protozoan parasite that causes Chagas disease. The parasite life cycle involves hematophagous reduviid bugs as vectors. Once parasites enter the host body, they invade diverse host cells including cardiomyocytes. Establishment of infection depends on various parasite molecules such as cruzipain, oligopeptidase B, and trans-sialidase that activate Ca2+ signaling. Internalized parasites escape from the parasitophorous vacuole using secreted pore-forming TcTOX molecule and replicate in the cytosol. Multiplied parasites eventually lyse infected host cells and are released in the circulation. During these events, the parasites manipulate host innate immunity and elicit cardiomyocyte hypertrophy. T lymphocyte responses are also disturbed

external resources
NCBI:147809
KEGG:hsa05142
PUBMED:12377585
PUBMED:9794425
PUBMED:1717552
PUBMED:16238097
PUBMED:10066513
PUBMED:12874238
PUBMED:12036740
PUBMED:15917295
PUBMED:12055254
PUBMED:17651955
PUBMED:1396957
PUBMED:16175174
PUBMED:2194668
PUBMED:9190942
PUBMED:12377942
PUBMED:12427093
PUBMED:10234174
PUBMED:16030288
PUBMED:15223603
PUBMED:17110955

genes
ADCY1 , AKT1 , AKT2 , FAS , FASLG , BDKRB2 , C1QA , C1QB , C1QC , C3 , CALR , CASP8 , CD3D , CD3E , CD3G , CD247 , CHUK , MAPK14 , ACE , FOS , GNA11 , GNA15 , GNAI1 , GNAI2 , GNAI3 , GNAL , GNAO1 , GNAQ , GNAS , IFNB1 , IFNG , IFNGR1 , IFNGR2 , IKBKB , IL1B , IL2 , IL6 , CXCL8 , IL10 , IL12A , IL12B , IRAK1 , JUN , SMAD2 , SMAD3 , MYD88 , NFKB1 , NFKBIA , NOS2 , SERPINE1 , PIK3CA , PIK3CB , PIK3CD , PIK3R1 , PIK3R2 , PLCB2 , PLCB3 , PLCB4 , PPP2CA , PPP2CB , PPP2R1A , PPP2R1B , PPP2R2A , PPP2R2B , PPP2R2C , MAPK1 , MAPK3 , MAPK8 , MAPK11 , MAPK9 , MAPK10 , MAPK13 , RELA , MAPK12 , CCL2 , CCL3 , CCL3L1 , CCL5 , MAP2K4 , TGFB1 , TGFB2 , TGFB3 , TGFBR1 , TGFBR2 , TLR2 , TLR4 , TNF , TNFRSF1A , TRAF6 , PIK3R3 , IKBKG , FADD , CFLAR , GNA14 , AKT3 , TLR6 , PLCB1 , IRAK4 , TLR9 , PPP2R2D , TICAM1 , CCL3L3 ,