description
Many pathogenic bacteria can invade phagocytic and non-phagocytic cells and colonize them intracellularly, then become disseminated to other cells. Invasive bacteria induce their own uptake by non-phagocytic host cells (e.g. epithelial cells) using two mechanisms referred to as zipper model and trigger model. Listeria, Staphylococcus, Streptococcus, and Yersinia are examples of bacteria that enter using the zipper model. These bacteria express proteins on their surfaces that interact with cellular receptors, initiating signalling cascades that result in close apposition of the cellular membrane around the entering bacteria. Shigella and Salmonella are the examples of bacteria entering cells using the trigger model. These bacteria use type III secretion systems to inject protein effectors that interact with the actin cytoskeleton

external resources
NCBI:149807
KEGG:hsa05100
PUBMED:17298394
PUBMED:16406780
PUBMED:19185531
PUBMED:19157959
PUBMED:17719540
PUBMED:19296488

genes
ACTB , ACTG1 , RHOA , RHOG , CAV1 , CAV2 , CAV3 , CBL , CBLB , CDC42 , CDH1 , CLTA , CLTB , CLTC , CRK , CRKL , CTNNA1 , CTNNA2 , CTNNB1 , SEPT1 , DNM1 , DNM2 , DOCK1 , CTTN , FN1 , GAB1 , HCLS1 , ILK , ITGA5 , ITGB1 , MET , SEPT2 , PIK3CA , PIK3CB , PIK3CD , PIK3R1 , PIK3R2 , PTK2 , PXN , RAC1 , SHC1 , SRC , VCL , WAS , CLTCL1 , PIK3R3 , WASF1 , WASL , BCAR1 , ELMO1 , ARPC5 , ARPC4 , ARPC3 , ARPC1B , ARPC2 , WASF2 , MAD2L2 , ARPC1A , SEPT9 , SEPT6 , SEPT8 , CD2AP , CBLC , SHC2 , DNM3 , ARHGEF26 , CTNNA3 , SHC3 , SEPT11 , SEPT3 , ELMO2 , ARHGAP10 , ELMO3 , ARPC5L , SEPT12 , SHC4 ,