description
Plasmodium protozoa are parasites that account for malaria infection. Sporozoite forms of the parasite are injected by mosquito bites under the skin and are carried to the liver where they develop into the merozoite form. Sporozoite invasion of hepatocytes is mediated by parasite surface protein like CSP. Subsequent infection into red blood cells (RBCs) by merozoites causes malaria disease via aberrant cytokine production and sequestration of parasite-infected red blood cells (pRBCs) to host endothelium. Microvasculature sequestration in the brain brings about cerebral malaria that can results in death or persisting neurological impairment. PfEMP1 has been suggested as the key adhesive molecule of pRBCs

external resources
NCBI:152665
KEGG:hsa05144
PUBMED:15106591
PUBMED:11224682
PUBMED:17630968
PUBMED:18250459
PUBMED:16138104
PUBMED:20091081
PUBMED:8920859
PUBMED:19101208
PUBMED:16019257
PUBMED:15464448
PUBMED:11832955
PUBMED:12364790
PUBMED:10885986
PUBMED:15094163
PUBMED:14737184
PUBMED:15463497
PUBMED:16468982
PUBMED:19967139

genes
CD36 , CD40 , CD40LG , CD81 , COMP , CR1 , CSF3 , ACKR1 , GYPA , GYPB , GYPC , HBA1 , HBA2 , HBB , HGF , ICAM1 , IFNG , IL1B , IL6 , CXCL8 , IL10 , IL12A , IL18 , ITGAL , ITGB2 , KLRB1 , LRP1 , MET , MYD88 , PECAM1 , CCL2 , SDC1 , SDC2 , SELE , SELP , TGFB1 , TGFB2 , TGFB3 , THBS1 , THBS2 , THBS3 , THBS4 , TLR2 , TLR4 , TNF , VCAM1 , KLRK1 , TLR9 , KLRC4-KLRK1 ,