description
Saliva has manifold functions in maintaining the integrity of the oral tissues, in protecting teeth from caries, in the tasting and ingestion of food, in speech and in the tolerance of tenures, for example. Salivary secretion occurs in response to stimulation by neurotransmitters released from autonomic nerve endings. There are two secretory pathways: protein exocytosis and fluid secretion. Sympathetic stimulation leads to the activation of adenylate cyclase and accumulation of intracellular cAMP. The elevation of cAMP causes the secretion of proteins such as amylase and mucin. In contrast, parasympathetic stimulation activates phospholipase C and causes the elevation of intracellular Ca2+, which leads to fluid secretion; that is, water and ion transport. Ca2+ also induces amylase secretion, but the amount is smaller than that induced by cAMP

external resources
NCBI:153376
KEGG:hsa04970
PUBMED:8105741
PUBMED:10682899
PUBMED:10928320
PUBMED:15709965
PUBMED:17347411
PUBMED:9720759
PUBMED:16712780
PUBMED:16799262
PUBMED:17157080
PUBMED:18626068
PUBMED:15153696
PUBMED:11936453
PUBMED:20224180

genes
ADCY1 , ADCY2 , ADCY3 , ADCY5 , ADCY6 , ADCY7 , ADCY8 , ADCY9 , ADRA1D , ADRA1B , ADRA1A , ADRB1 , ADRB2 , ADRB3 , AMY1A , AMY1B , AMY1C , AQP5 , ATP1A1 , ATP1A2 , ATP1A3 , ATP1A4 , ATP1B1 , ATP1B2 , ATP1B3 , FXYD2 , ATP2B1 , ATP2B2 , ATP2B3 , ATP2B4 , BST1 , CALM1 , CALM2 , CALM3 , CALML3 , CAMP , CD38 , CHRM3 , CST1 , CST2 , CST3 , CST4 , CST5 , DMBT1 , GNAQ , GNAS , GUCY1A2 , GUCY1A1 , GUCY1B1 , HTN1 , HTN3 , ITPR1 , ITPR2 , ITPR3 , KCNMA1 , KCNN4 , LPO , LYZ , MUC7 , NOS1 , PLCB2 , PLCB3 , PLCB4 , PRB1 , PRH1 , PRH2 , PRKACA , PRKACB , PRKACG , PRKCA , PRKCB , PRKCG , PRKG1 , PRKG2 , RYR3 , SLC4A2 , SLC9A1 , SLC12A2 , STATH , VAMP2 , PLCB1 , ATP1B4 , CALML5 , BEST2 , TRPV6 , CALML4 , CALML6 , ADCY4 , PRB2 , MUC5B ,