description
Gastric acid is a key factor in normal upper gastrointestinal functions, including protein digestion and calcium and iron absorption, as well as providing some protection against bacterial infections. The principal stimulants of acid secretion at the level of the parietal cell are histamine (paracrine), gastrin (hormonal), and acetycholine (ACh; neurocrine). Stimulation of acid secretion typically involves an initial elevation of intracellular calcium and cAMP, followed by activation of protein kinase cascades, which trigger the translocation of the proton pump, H+,K+-ATPase, from cytoplasmic tubulovesicles to the apical plasma membrane and thereby H+ secretion into the stomach lumen

external resources
NCBI:154409
KEGG:hsa04971
PUBMED:17928547
PUBMED:18474247
PUBMED:20148676
PUBMED:15703676
PUBMED:15579540
PUBMED:18626068
PUBMED:20331540
PUBMED:19889964
PUBMED:12500969
PUBMED:16391411
PUBMED:9307437
PUBMED:18061403

genes
ACTB , ADCY1 , ADCY2 , ADCY3 , ADCY5 , ADCY6 , ADCY7 , ADCY8 , ADCY9 , ATP1A1 , ATP1A2 , ATP1A3 , ATP1A4 , ATP1B1 , ATP1B2 , ATP1B3 , ATP4A , ATP4B , CA2 , CALM1 , CALM2 , CALM3 , CALML3 , CAMK2A , CAMK2B , CAMK2D , CAMK2G , CCKBR , CFTR , CHRM3 , GAST , GNAI1 , GNAI2 , GNAI3 , GNAQ , GNAS , HRH2 , ITPR1 , ITPR2 , ITPR3 , KCNJ1 , KCNJ2 , KCNJ10 , KCNJ15 , KCNJ16 , KCNK2 , KCNQ1 , MYLK , PLCB2 , PLCB3 , PLCB4 , PRKACA , PRKACB , PRKACG , PRKCA , PRKCB , PRKCG , SLC4A2 , SLC9A1 , SST , SSTR2 , EZR , KCNE2 , PLCB1 , ATP1B4 , CALML5 , KCNK10 , MYLK2 , MYLK3 , CALML4 , SLC26A7 , CALML6 , ADCY4 , MYLK4 , SLC9A4 ,