description
Entamoeba histolytica, an extracellular protozoan parasite is a human pathogen that invades the intestinal epithelium. Infection occurs on ingestion of contaminated water and food. The pathogenesis of amoebiasis begins with parasite attachment and disruption of the intestinal mucus layer, followed by apoptosis of host epithelial cells. Intestinal tissue destruction causes severe dysentery and ulcerations in amoebic colitis. Several amoebic proteins such as lectins, cysteine proteineases, and amoebapores are associated with the invasion process. The parasite can cause extraintestinal infection like amoebic liver abscess by evading immune response

external resources
NCBI:167324
KEGG:hsa05146
PUBMED:9832261
PUBMED:16380324
PUBMED:14700586
PUBMED:18725798
PUBMED:12142490
PUBMED:10637584
PUBMED:20145703
PUBMED:11378035
PUBMED:12160867
PUBMED:15813717
PUBMED:19207103
PUBMED:12660071
PUBMED:20303955
PUBMED:11352795
PUBMED:14502002
PUBMED:10756002
PUBMED:17702556
PUBMED:17576362

genes
ACTN4 , ACTN1 , ADCY1 , ARG1 , ARG2 , C8A , C8B , C8G , C9 , CASP3 , CD1D , CD14 , COL1A1 , COL1A2 , COL3A1 , COL4A1 , COL4A2 , COL4A3 , COL4A4 , COL4A5 , COL4A6 , CSF2 , CTSG , SERPINB1 , FN1 , GNA11 , GNA15 , GNAL , GNAQ , GNAS , CXCL1 , HSPB1 , IFNG , IL1B , IL1R1 , IL6 , CXCL8 , IL10 , IL12A , IL12B , ITGAM , ITGB2 , LAMA2 , LAMA3 , LAMA4 , LAMA5 , LAMB1 , LAMB2 , LAMB3 , LAMC1 , LAMC2 , MUC2 , NFKB1 , NOS2 , SERPINB6 , SERPINB9 , SERPINB10 , SERPINB13 , PIK3CA , PIK3CB , PIK3CD , PIK3R1 , PIK3R2 , PLCB2 , PLCB3 , PLCB4 , PRKACA , PRKACB , PRKACG , PRKCA , PRKCB , PRKCG , PTK2 , RAB5A , RAB5B , RAB5C , RELA , SERPINB3 , SERPINB4 , TGFB1 , TGFB2 , TGFB3 , TLR2 , TLR4 , TNF , VCL , IL1R2 , RAB7A , PIK3R3 , GNA14 , LAMC3 , LAMB4 , PLCB1 , LAMA1 ,