description
The pancreas performs both exocrine and endocrine functions. The exocrine pancreas consists of two parts, the acinar and duct cells. The primary functions of pancreatic acinar cells are to synthesize and secrete digestive enzymes. Stimulation of the cell by secretagogues such as acetylcholine (ACh) and cholecystokinin (CCK) causes the generation of an intracellular Ca2+ signal. This signal, in turn, triggers the fusion of the zymogen granules with the apical plasma membrane, leading to the polarised secretion of the enzymes. The major task of pancreatic duct cells is the secretion of fluid and bicarbonate ions (HCO3-), which neutralize the acidity of gastric contents that enter the duodenum. An increase in intracellular cAMP by secretin is one of the major signals of pancreatic HCO3- secretion. Activation of the CFTR Cl- channel and the CFTR-dependent Cl-/HCO3- exchange activities is responsible for cAMP-induced HCO3- secretion

external resources
NCBI:169306
KEGG:hsa04972
PUBMED:16888148
PUBMED:9548666
PUBMED:20224219
PUBMED:19088252
PUBMED:15709963
PUBMED:10078532
PUBMED:15689674
PUBMED:10835353
PUBMED:14660554
PUBMED:20625287
PUBMED:16930743
PUBMED:14637169
PUBMED:16891880
PUBMED:18626068
PUBMED:11087843
PUBMED:17850212
PUBMED:17205399

genes
ADCY1 , ADCY2 , ADCY3 , ADCY5 , ADCY6 , ADCY7 , ADCY8 , ADCY9 , AMY2A , AMY2B , RHOA , ATP1A1 , ATP1A2 , ATP1A3 , ATP1A4 , ATP1B1 , ATP1B2 , ATP1B3 , FXYD2 , ATP2A1 , ATP2A2 , ATP2A3 , ATP2B1 , ATP2B2 , ATP2B3 , ATP2B4 , BST1 , CA2 , CCKAR , CD38 , CEL , CFTR , CHRM3 , CLCA1 , CPA1 , CPA2 , CPA3 , CPB1 , CPB2 , CTRB1 , CTRL , SLC26A3 , GNAQ , GNAS , ITPR1 , ITPR2 , ITPR3 , KCNMA1 , KCNQ1 , RAB8A , PLA2G1B , PLA2G2A , PLA2G5 , PLCB2 , PLCB3 , PLCB4 , PNLIP , PNLIPRP1 , PNLIPRP2 , PRKCA , PRKCB , PRKCG , PRSS1 , PRSS3 , RAB27B , RAC1 , RAP1A , RAP1B , RYR2 , SCTR , SLC4A2 , SLC9A1 , SLC12A2 , TRPC1 , PLA2G10 , SLC4A4 , RAB11A , RAB3D , CLCA2 , CELA3A , CLCA4 , PLCB1 , CELA3B , ATP1B4 , PLA2G2D , PLA2G2E , PLA2G3 , CELA2B , CELA2A , PLA2G2F , PLA2G12A , PLA2G12B , ADCY4 , TPCN2 , PLA2G2C ,