description
Hepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the cytoplasm of the host cell and forms membrane-associated replication complexes along with non-structural proteins. Viral RNA can trigger the RIG-I pathway and interferon production during this process. Translated HCV protein products regulate immune response to inhibit the action of interferon. HCV core and NS5A proteins appear to be the most important molecules with regulatory functions that modulate transcription, cellular proliferation, and apoptosis

external resources
NCBI:173973
KEGG:hsa05160
PUBMED:19708811
PUBMED:16314558
PUBMED:17467654
PUBMED:19515018
PUBMED:18514579
PUBMED:16107833
PUBMED:19074178
PUBMED:12691459
PUBMED:15302943
PUBMED:20537953
PUBMED:11991644
PUBMED:19148799
PUBMED:19187070
PUBMED:12655344

genes
AKT1 , AKT2 , ARAF , BAD , BRAF , SCARB1 , CD81 , CDKN1A , CHUK , CLDN4 , CLDN3 , CLDN7 , MAPK14 , EGF , EGFR , EIF2S1 , GRB2 , GSK3B , HRAS , IFIT1 , IFNA1 , IFNA2 , IFNA4 , IFNA5 , IFNA6 , IFNA7 , IFNA8 , IFNA10 , IFNA13 , IFNA14 , IFNA16 , IFNA17 , IFNA21 , IFNAR1 , IFNAR2 , IFNB1 , IKBKB , CXCL8 , EIF3E , IRF1 , IRF3 , IRF7 , JAK1 , KRAS , LDLR , NFKB1 , NFKBIA , NRAS , OAS1 , OAS2 , OAS3 , CLDN11 , PDPK1 , PIK3CA , PIK3CB , PIK3CD , PIK3R1 , PIK3R2 , PPARA , PPP2CA , PPP2CB , PPP2R1A , PPP2R1B , PPP2R2A , PPP2R2B , PPP2R2C , MAPK1 , MAPK3 , MAPK8 , MAPK11 , MAPK9 , MAPK10 , MAPK13 , EIF2AK2 , RAF1 , RELA , RNASEL , RXRA , MAPK12 , SOS1 , SOS2 , STAT1 , STAT2 , STAT3 , TLR3 , CLDN5 , TNF , TNFRSF1A , TP53 , TRAF2 , TRAF3 , TRAF6 , TYK2 , PIK3R3 , IKBKG , PIAS1 , TRADD , RIPK1 , SOCS3 , CLDN10 , CLDN8 , CLDN6 , CLDN2 , CLDN1 , CLDN9 , EIF2AK3 , IKBKE , AKT3 , NR1H3 , PSME3 , IRF9 , CLDN16 , CLDN14 , DDX58 , CLDN15 , CLDN17 , EIF2AK1 , TBK1 , CLDN20 , CLDN18 , CLDN22 , PPP2R2D , MAVS , CLDN23 , TICAM1 , CLDN19 , IFIT1B , EIF2AK4 , CLDN25 , CLDN24 , OCLN ,