description
Bile is a vital secretion, essential for digestion and absorption of fats and fat-soluble vitamins in the small intestine. Moreover, bile is an important route of elimination for excess cholesterol and many waste product, bilirubin, drugs and toxic compounds. Bile secretion depends on the function of membrane transport systems in hepatocytes and cholangiocytes and on the structural and functional integrity of the biliary tree. The hepatocytes generate the so-called primary bile in their canaliculi. Cholangiocytes modify the canalicular bile by secretory and reabsorptive processes as bile passes through the bile ducts. The main solutes in bile are bile acids, which stimulate bile secretion osmotically, as well as facilitate the intestinal absorption of dietary lipids by their detergent properties. Bile acids are also important signalling molecules. Through the activation of nuclear receptors, they regulate their own synthesis and transport rates

external resources
NCBI:193146
KEGG:hsa04976
PUBMED:11826283
PUBMED:19273385
PUBMED:12663868
PUBMED:15758646
PUBMED:18837079
PUBMED:15975683
PUBMED:17404808
PUBMED:18377365
PUBMED:16706681
PUBMED:10728790
PUBMED:14659471
PUBMED:18670431
PUBMED:12483266
PUBMED:19273238
PUBMED:18668439
PUBMED:18371245
PUBMED:14999673
PUBMED:11316487
PUBMED:18081658
PUBMED:19482594
PUBMED:20103563

genes
ADCY1 , ADCY2 , ADCY3 , ADCY5 , ADCY6 , ADCY7 , ADCY8 , ADCY9 , AQP8 , AQP1 , AQP4 , AQP9 , ATP1A1 , ATP1A2 , ATP1A3 , ATP1A4 , ATP1B1 , ATP1B2 , ATP1B3 , FXYD2 , BAAT , CA2 , SCARB1 , CFTR , ABCC2 , CYP3A4 , CYP7A1 , EPHX1 , GNAS , HMGCR , KCNN2 , LDLR , ABCB1 , ABCB4 , PRKACA , PRKACB , PRKACG , RXRA , SCTR , SLC2A1 , SLC4A2 , SLC5A1 , SLC9A1 , SLC9A3 , SLC10A1 , SLC10A2 , SLCO1A2 , SLC22A1 , SULT2A1 , UGT2B4 , NR0B2 , ABCB11 , SLC4A4 , ABCC3 , SLC22A8 , ABCG2 , NR1H4 , ABCC4 , SLCO1B1 , SLC22A7 , SLC27A5 , ATP1B4 , SLCO1B3 , NCEH1 , SLC4A5 , ABCG5 , ABCG8 , SLC51B , ADCY4 , SLC51A , SLCO1B7 ,