description
The osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways activated by RANK and immune receptors, whose ligands are expressed on the surface of osteoblasts. Signaling from RANK changes gene expression patterns through transcription factors like NFATc1 and characterizes the active osteoclast

external resources
NCBI:193147
KEGG:hsa04380
PUBMED:17633024
PUBMED:18382763
PUBMED:18329366
PUBMED:17869613
PUBMED:18722561
PUBMED:15122243
PUBMED:20703218
PUBMED:12748652
PUBMED:12110142
PUBMED:19585227
PUBMED:15546140
PUBMED:16184196
PUBMED:15817678
PUBMED:20392226
PUBMED:16313349
PUBMED:16313342
PUBMED:17380158
PUBMED:18451259

genes
ACP5 , AKT1 , AKT2 , BTK , CALCR , CAMK4 , CHUK , CREB1 , MAPK14 , CSF1 , CSF1R , CTSK , CYBA , CYBB , CYLD , FCGR1A , FCGR2A , FCGR2B , FCGR3A , FCGR3B , FHL2 , FOS , FOSB , FOSL2 , FYN , GRB2 , IFNAR1 , IFNAR2 , IFNB1 , IFNG , IFNGR1 , IFNGR2 , IKBKB , IL1A , IL1B , IL1R1 , ITGB3 , JAK1 , JUN , JUNB , JUND , LCK , LCP2 , MITF , NCF2 , NCF4 , NFATC1 , NFATC2 , NFKB1 , NFKB2 , NFKBIA , TNFRSF11B , PIK3CA , PIK3CB , PIK3CD , PIK3R1 , PIK3R2 , PLCG2 , PPARG , PPP3CA , PPP3CB , PPP3CC , PPP3R1 , PPP3R2 , MAPK1 , MAPK3 , MAPK8 , MAPK11 , MAPK9 , MAPK10 , MAPK13 , MAP2K1 , MAP2K6 , MAP2K7 , RAC1 , RELA , RELB , MAPK12 , SPI1 , STAT1 , STAT2 , SYK , MAP3K7 , TEC , TGFB1 , TGFB2 , TGFBR1 , TGFBR2 , TNF , TNFRSF1A , TRAF2 , TRAF6 , TYK2 , TYROBP , FOSL1 , PIK3R3 , IKBKG , TNFSF11 , SOCS1 , TNFRSF11A , SQSTM1 , MAP3K14 , SOCS3 , FCGR2C , GAB2 , AKT3 , LILRB2 , SIRPB1 , IRF9 , TAB1 , LILRB1 , LILRB5 , LILRB4 , LILRA1 , LILRB3 , LILRA3 , LILRA2 , TAB2 , LILRA4 , NOX1 , BLNK , NOX3 , TREM2 , SIRPG , LILRA6 , OSCAR , SIRPA , LILRA5 , NCF1 ,