description
Trypanosoma brucei, the parasite responsible for African trypanosomiasis (sleeping sickness), are spread by the tsetse fly in sub-Saharan Africa. The parasites are able to pass through the blood-brain barrier and cause neurological damage by inducing cytokines like TNF alpha, IFN gamma, and IL1. These cytokines and other metabolites such as nitric oxide and somnogenic prostaglandin D2 disturb circadian rhythms in patients with African trypanosomiasis

external resources
NCBI:194384
KEGG:hsa05143
PUBMED:9574925
PUBMED:12088284
PUBMED:19559585
PUBMED:20398209
PUBMED:17582444
PUBMED:19168735
PUBMED:19016378
PUBMED:11850009
PUBMED:16600243
PUBMED:19995590
PUBMED:19621073

genes
APOA1 , FAS , FASLG , F2RL1 , GNAQ , HBA1 , HBA2 , HBB , HPR , ICAM1 , IFNG , IL1B , IL6 , IL10 , IL12A , IL12B , IL18 , IDO1 , LAMA4 , MYD88 , PLCB2 , PLCB3 , PLCB4 , PRKCA , PRKCB , PRKCG , SELE , THOP1 , TNF , VCAM1 , APOL1 , PLCB1 , TLR9 , IDO2 ,