description
Rheumatoid arthritis (RA) is a chronic autoimmune joint disease where persistent inflammation affects bone remodeling leading to progressive bone destruction. In RA, abnormal activation of the immune system elevates pro-inflammatory cytokines and chemokines levels, which can promote synovial angiogenesis and leukocyte infiltration. The synovium forms a hyperplastic pannus with infiltrated macrophage-like and fibroblast-like synoviocytes and invades joints by secreting proteinases and inducing osteoclast differentiation

external resources
NCBI:200309
KEGG:hsa05323
PUBMED:9627005
PUBMED:17195034
PUBMED:15059264
PUBMED:17380158
PUBMED:20651747
PUBMED:19455385
PUBMED:20305562
PUBMED:20510236
PUBMED:19184540
PUBMED:20392226
PUBMED:17502360
PUBMED:16313349
PUBMED:16127012
PUBMED:15055519
PUBMED:20036936
PUBMED:11861618
PUBMED:19585227
PUBMED:20193003

genes
ACP5 , ANGPT1 , ATP6V1A , ATP6V1B1 , ATP6V1B2 , ATP6V0C , ATP6V1C1 , ATP6V1E1 , ATP6V0B , ATP6V1G2 , ATP6V0A1 , ATP6AP1 , CD28 , CD80 , CD86 , CSF1 , CSF2 , CTLA4 , CTSK , CTSL , FLT1 , FOS , CXCL1 , HLA-DMA , HLA-DMB , HLA-DOA , HLA-DOB , HLA-DPA1 , HLA-DPB1 , HLA-DQA1 , HLA-DQA2 , HLA-DQB1 , HLA-DRA , HLA-DRB1 , HLA-DRB5 , ICAM1 , IFNG , IL1A , IL1B , IL6 , CXCL8 , IL11 , IL15 , IL17A , IL18 , ITGAL , ITGB2 , JUN , LTB , MMP1 , MMP3 , CCL2 , CCL3 , CCL3L1 , CCL5 , CCL20 , CXCL6 , CXCL5 , CXCL12 , TEK , TGFB1 , TGFB2 , TGFB3 , TLR2 , TLR4 , TNF , VEGFA , TNFSF11 , TNFSF13 , TNFRSF11A , ATP6V0E1 , ATP6V0D1 , ATP6V1F , ATP6V1G1 , TCIRG1 , TNFSF13B , ATP6V0A2 , ATP6V0A4 , ATP6V1D , IL23A , ATP6V1H , ATP6V1E2 , ATP6V1G3 , ATP6V0E2 , ATP6V0D2 , ATP6V1C2 , CCL3L3 ,