description
Measles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacterial infections. Several MV proteins have been suggested to disturb host immunity. After infection of host lymphoid cells via SLAM, MV inhibits cytokine response by direct interference with host signaling systems. Three proteins (P, V, and C) associate with Jak/STAT proteins in interferon-triggered pathway and other important proteins related to apoptosis. Interaction between MV and host brings about the shift towards a Th2 response by decreasing IL-12 production and induces lymphopenia by suppressing cell proliferation

external resources
NCBI:213306
KEGG:hsa05162
PUBMED:16237742
PUBMED:12804771
PUBMED:19198562
PUBMED:20376484
PUBMED:11385511
PUBMED:16963735
PUBMED:19198566
PUBMED:18922877
PUBMED:19203114
PUBMED:12620806
PUBMED:16690907
PUBMED:17720800
PUBMED:20636817
PUBMED:12410527
PUBMED:11582511
PUBMED:19203109
PUBMED:19203113
PUBMED:14585342
PUBMED:12805463

genes
ADAR , AKT1 , AKT2 , FAS , FASLG , CCND1 , CBLB , CCND2 , CCND3 , CCNE1 , CD3D , CD3E , CD3G , CD28 , CDK2 , CDK4 , CDK6 , CDKN1B , CHUK , CSNK2A1 , CSNK2A2 , CSNK2B , DOK1 , EIF2S1 , FCGR2B , FYN , GSK3B , HSPA1A , HSPA1B , HSPA1L , HSPA2 , HSPA6 , HSPA8 , IFNA1 , IFNA2 , IFNA4 , IFNA5 , IFNA6 , IFNA7 , IFNA8 , IFNA10 , IFNA13 , IFNA14 , IFNA16 , IFNA17 , IFNA21 , IFNAR1 , IFNAR2 , IFNB1 , IFNG , IFNGR1 , IFNGR2 , IL1A , IL1B , IL2 , IL2RA , IL2RB , IL2RG , IL4 , IL6 , IL12A , IL12B , IL13 , IRAK1 , IRF3 , IRF7 , JAK1 , JAK2 , JAK3 , SH2D1A , CD46 , MSN , MX1 , MYD88 , NFKB1 , NFKBIA , NFKBIB , OAS1 , OAS2 , OAS3 , PIK3CA , PIK3CB , PIK3CD , PIK3R1 , PIK3R2 , PRKCQ , EIF2AK2 , RELA , SLAMF1 , STAT1 , STAT2 , STAT3 , STAT5A , STAT5B , TACR1 , MAP3K7 , TLR2 , TLR4 , TNFAIP3 , TP53 , TP73 , TRAF6 , TYK2 , PIK3R3 , EIF3H , TNFSF10 , TNFRSF10D , TNFRSF10C , TNFRSF10B , TNFRSF10A , CCNE2 , RAB9A , EIF2AK3 , IKBKE , AKT3 , CLEC4M , IRF9 , RACK1 , TAB2 , DDX58 , RCHY1 , EIF2AK1 , BBC3 , TBK1 , CD209 , IRAK4 , RAB9B , TLR7 , TLR9 , MAVS , IFIH1 , CSNK2A3 , EIF2AK4 ,