description
Calcium (Ca2+) is essential for numerous physiological functions including intracellular signalling processes, neuronal excitability, muscle contraction and bone formation. Therefore, its homeostasis is finely maintained through the coordination of intestinal absorption, renal reabsorption, and bone resorption. In kidney, the late part of the distal convoluted tubule (DCT) and the connecting tubule (CNT) are the site of active Ca2+ transport and precisely regulate Ca2+ reabsorption. Following Ca2+ entry through TRPV5, Ca2+ bound to calbindin-D28K diffuses to the basolateral side, where it is extruded into the blood compartment through NCX1 and to a lesser extent PMCA1b. In the urinary compartment, both klotho and tissue kallikrein (TK) increase the apical abundance of TRPV5. In the blood compartment, PTH, 1,25(OH)2D3 and estrogen increase the transcription and protein expression of the luminal Ca2+ channels, calbindins, and the extrusion systems

external resources
NCBI:213307
KEGG:hsa04961
PUBMED:15747113
PUBMED:20969972
PUBMED:15618484
PUBMED:18989697
PUBMED:19423690
PUBMED:18293139
PUBMED:18596722
PUBMED:16518325
PUBMED:17006539
PUBMED:12684797
PUBMED:17233615
PUBMED:16044309

genes
ADCY6 , ADCY9 , AP2A1 , AP2A2 , AP2B1 , ATP1A1 , ATP1A2 , ATP1A3 , ATP1A4 , ATP1B1 , ATP1B2 , ATP1B3 , FXYD2 , ATP2B1 , BDKRB2 , CALB1 , AP2M1 , AP2S1 , CLTA , CLTB , CLTC , DNM1 , DNM2 , ESR1 , GNAQ , GNAS , KLK1 , KLK2 , PLCB2 , PLCB3 , PLCB4 , PRKACA , PRKACB , PRKACG , PRKCA , PRKCB , PRKCG , PTH1R , SLC8A1 , VDR , CLTCL1 , RAB11A , KL , PLCB1 , ATP1B4 , DNM3 , TRPV5 ,