description
Tuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent infections, and about 10% of latent infections develop active diseases when their immune system is impaired due to the age, other diseases such as AIDS or exposure to immunosuppressive drugs. TB is transmitted through the air and primarily attacks the lungs, then it can spread by the circulatory system to other parts of body. Once TB bacilli have entered the host by the respiratory route and infected macrophages in the lungs, they interfere with phagosomal maturation, antigen presentation, apoptosis and host immune system to establish persistent or latent infection

external resources
NCBI:213780
KEGG:hsa05152
PUBMED:20199890
PUBMED:21274449
PUBMED:17359235
PUBMED:20415982
PUBMED:18541216
PUBMED:19369951
PUBMED:15083155
PUBMED:11378475
PUBMED:15228522
PUBMED:19634703
PUBMED:21274433
PUBMED:19563525
PUBMED:18407066
PUBMED:18288961
PUBMED:16200082
PUBMED:17785780
PUBMED:11932234

genes
AKT1 , AKT2 , APAF1 , RHOA , ATP6V0C , ATP6V0B , ATP6V0A1 , ATP6AP1 , BAD , BAX , BCL2 , BID , C3 , CALM1 , CALM2 , CALM3 , CALML3 , CAMK2A , CAMK2B , CAMK2D , CAMK2G , CAMP , CASP3 , CASP8 , CASP9 , CASP10 , CD14 , CD74 , CEBPB , CEBPG , PLK3 , CR1 , CREB1 , CREBBP , MAPK14 , CTSD , CTSS , CYP27B1 , EP300 , FCER1G , FCGR1A , FCGR2A , FCGR2B , FCGR3A , FCGR3B , HLA-DMA , HLA-DMB , HLA-DOA , HLA-DOB , HLA-DPA1 , HLA-DPB1 , HLA-DQA1 , HLA-DQA2 , HLA-DQB1 , HLA-DRA , HLA-DRB1 , HLA-DRB5 , HSPA9 , HSPD1 , IFNA1 , IFNA2 , IFNA4 , IFNA5 , IFNA6 , IFNA7 , IFNA8 , IFNA10 , IFNA13 , IFNA14 , IFNA16 , IFNA17 , IFNA21 , IFNB1 , IFNG , IFNGR1 , IFNGR2 , IL1A , IL1B , IL6 , IL10 , IL10RA , IL10RB , IL12A , IL12B , IL18 , IRAK1 , IRAK2 , ITGAM , ITGAX , ITGB2 , JAK1 , JAK2 , LAMP1 , LAMP2 , LBP , LSP1 , CIITA , MRC1 , MYD88 , NFKB1 , NFYA , NFYB , NFYC , NOS2 , PIK3C3 , PPP3CA , PPP3CB , PPP3CC , PPP3R1 , PPP3R2 , MAPK1 , MAPK3 , MAPK8 , MAPK11 , MAPK9 , MAPK10 , MAPK13 , RAB5A , RAB5B , RAB5C , RAF1 , RELA , RFX5 , RFXAP , MAPK12 , SRC , STAT1 , SYK , TGFB1 , TGFB2 , TGFB3 , TLR1 , TLR2 , TLR4 , TNF , TNFRSF1A , TRAF6 , VDR , RAB7A , EEA1 , RFXANK , TRADD , RIPK2 , FADD , KSR1 , SPHK1 , BCL10 , FCGR2C , ATP6V0D1 , MRC2 , AKT3 , TCIRG1 , CLEC4M , TLR6 , MALT1 , CORO1A , PLA2R1 , ARHGEF12 , ATP6V0A2 , CLEC4E , CD209 , ATP6V0A4 , IRAK4 , IL23A , ATP6V1H , CALML5 , TLR9 , CYCS , SPHK2 , NOD2 , CARD9 , CLEC7A , CALML4 , TIRAP , CALML6 , ATP6V0D2 ,