description
Pertussis, also known as whooping cough, is an acute respiratory infectious disease caused by a bacteria called Bordetella Pertussis. The characteristic symptoms are paroxysmal cough, inspiratory wheezing and post-tussive vomiting. Following the inhalation of respiratory secretions from an infected individual, bacteria enter the upper respiratory tract and adhere to epithelial cells. Several adhesion factors have been implicated: the filamentous hemagglutinin (FHA), fimbriae, and pertactin (Prn). Pertussis toxin (Ptx) and adenylate cyclase toxin (ACT) have been identified so far as major protein toxins of B. pertussis. PTX is a hexameric AB5-type exotoxin. Catalytic A subunit catalyzes the ADP-ribosylation of the Gi subunits of the heterotrimeric G protein, then inhibits multiple downstream pathways. ACT is able to penetrate the cytoplasmic membrane of host cells and becomes activated through the cleavage and the binding of calmodulin (CaM). Activated ACT converts ATP to cyclic AMP and subverts cellular signaling pathways

external resources
NCBI:218111
KEGG:hsa05133
PUBMED:20610650
PUBMED:12701623
PUBMED:15201703
PUBMED:18401006
PUBMED:20210554
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PUBMED:16999837
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PUBMED:16390441
PUBMED:21423776
PUBMED:17328678
PUBMED:12915094

genes
RHOA , SERPING1 , C1QA , C1QB , C1QC , C1R , C1S , C2 , C3 , C4A , C4B , C4BPA , C4BPB , C5 , CALM1 , CALM2 , CALM3 , CALML3 , CASP1 , CASP3 , CASP7 , CD14 , CFL1 , CFL2 , MAPK14 , FOS , GNAI1 , GNAI2 , GNAI3 , IRF8 , IL1A , IL1B , IL6 , CXCL8 , IL10 , IL12A , IL12B , IRAK1 , IRF1 , IRF3 , ITGA5 , ITGAM , ITGB1 , ITGB2 , JUN , MYD88 , NFKB1 , NOS2 , MAPK1 , MAPK3 , MAPK8 , MAPK11 , MAPK9 , MAPK10 , MAPK13 , RELA , MAPK12 , CXCL6 , CXCL5 , TLR4 , TNF , TRAF6 , NOD1 , LY96 , PYCARD , IRAK4 , IL23A , CALML5 , CALML4 , NLRP3 , TIRAP , TICAM1 , CALML6 , TICAM2 , SFTPA1 , SFTPA2 ,