description
Communication between neurons is mediated by the release of neurotransmitter from synaptic vesicles (SVs). At the nerve terminal, SVs cycle through repetitive episodes of exocytosis and endocytosis. SVs are filled with neurotransmitters by active transport. The loaded SVs are then docked at a specialized region of the presynaptic plasma membrane known as the active zone, where they undergo a priming reaction. Upon arrival of an action potential, Ca2+ enters through voltage-gated channels and neurotransmitter is released by exocytosis, usually in less than a millisecond. After fusion, the vesicle is retrieved by endocytosis and reloaded for another round of exocytosis

external resources
NCBI:373900
KEGG:hsa04721
PUBMED:20634814
PUBMED:17767192
PUBMED:12094216
PUBMED:16990140
PUBMED:18726177
PUBMED:18275379
PUBMED:12827282
PUBMED:12154365
PUBMED:10212473
PUBMED:15217342
PUBMED:7791897
PUBMED:12563290

genes
AP2A1 , AP2A2 , AP2B1 , ATP6V1A , ATP6V1B1 , ATP6V1B2 , ATP6V0C , ATP6V1C1 , ATP6V1E1 , ATP6V0B , ATP6V1G2 , ATP6V0A1 , CACNA1A , CACNA1B , AP2M1 , AP2S1 , CLTA , CLTB , CLTC , DNM1 , DNM2 , STX2 , NSF , RAB3A , SLC18A1 , SLC18A2 , SLC18A3 , SNAP25 , STX1A , STX3 , STXBP1 , VAMP2 , SYT1 , CLTCL1 , NAPA , ATP6V0E1 , ATP6V0D1 , ATP6V1F , ATP6V1G1 , TCIRG1 , UNC13B , CPLX2 , CPLX1 , RIMS1 , UNC13A , ATP6V0A2 , DNM3 , ATP6V0A4 , ATP6V1D , ATP6V1H , SLC17A7 , SLC17A6 , ATP6V1E2 , STX1B , ATP6V1G3 , SLC32A1 , ATP6V0E2 , ATP6V0D2 , ATP6V1C2 , SLC17A8 , CPLX4 , UNC13C , CPLX3 ,