description
Human T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammatory diseases such as HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Expression of Tax, a viral regulatory protein is critical to the pathogenesis. Tax is a transcriptional co-factor that interfere several signaling pathways related to anti-apoptosis or cell proliferation. The modulation of the signaling by Tax involve its binding to transcription factors like CREB/ATF, NF-kappa B, SRF, and NFAT
external resources
NCBI:373901
KEGG:hsa05166
PUBMED:17446673
PUBMED:16436385
PUBMED:14686485
PUBMED:19861996
PUBMED:19092975
PUBMED:11325603
PUBMED:16155602
PUBMED:12910251
PUBMED:16155605
PUBMED:16036567
PUBMED:11244044
PUBMED:18702816
PUBMED:15569630
PUBMED:21114861
PUBMED:16155611
PUBMED:17384582
PUBMED:16155608
PUBMED:10602469
PUBMED:19014483
PUBMED:9325311
genes
ADCY1
,
ADCY2
,
ADCY3
,
ADCY5
,
ADCY6
,
ADCY7
,
ADCY8
,
ADCY9
,
AKT1
,
AKT2
,
SLC25A4
,
SLC25A5
,
SLC25A6
,
APC
,
XIAP
,
ATF1
,
ATF3
,
ATF4
,
ATM
,
ATR
,
BAX
,
CCND1
,
BCL2L1
,
BUB1B
,
TSPO
,
CALR
,
CANX
,
CCND2
,
CCND3
,
CD3D
,
CD3E
,
CD3G
,
CD40
,
CDC20
,
CDC27
,
CDK4
,
CDKN1A
,
CDKN2A
,
CDKN2B
,
CDKN2C
,
CHEK1
,
CHUK
,
CREB1
,
ATF2
,
CREBBP
,
CREM
,
CSF2
,
CTNNB1
,
DLG1
,
DVL1
,
DVL2
,
DVL3
,
E2F1
,
E2F2
,
E2F3
,
EGR1
,
EGR2
,
ELK1
,
ELK4
,
EP300
,
ETS1
,
ETS2
,
FDPS
,
FOS
,
FZD2
,
KAT2A
,
GPS2
,
GSK3B
,
HLA-A
,
HLA-B
,
HLA-C
,
HLA-DMA
,
HLA-DMB
,
HLA-DOA
,
HLA-DOB
,
HLA-DPA1
,
HLA-DPB1
,
HLA-DQA1
,
HLA-DQA2
,
HLA-DQB1
,
HLA-DRA
,
HLA-DRB1
,
HLA-DRB5
,
HLA-E
,
HLA-F
,
HLA-G
,
HRAS
,
ICAM1
,
IKBKB
,
IL1R1
,
IL2
,
IL2RA
,
IL2RB
,
IL2RG
,
IL6
,
IL15
,
IL15RA
,
ITGAL
,
ITGB2
,
JAK1
,
JAK3
,
JUN
,
KRAS
,
LCK
,
LTA
,
LTBR
,
MAD2L1
,
SMAD2
,
SMAD3
,
SMAD4
,
MAP3K1
,
MAP3K3
,
MSX1
,
MSX2
,
MYB
,
MYBL1
,
MYBL2
,
MYC
,
NFATC1
,
NFATC2
,
NFATC3
,
NFATC4
,
NFKB1
,
NFKB2
,
NFKBIA
,
NFYB
,
NRAS
,
PCNA
,
PDGFA
,
PDGFB
,
PDGFRA
,
PDGFRB
,
PIK3CA
,
PIK3CB
,
PIK3CD
,
PIK3R1
,
PIK3R2
,
POLB
,
POLD1
,
POLD2
,
POLE
,
POLE2
,
PPP3CA
,
PPP3CB
,
PPP3CC
,
PPP3R1
,
PPP3R2
,
PRKACA
,
PRKACB
,
PRKACG
,
MAPK8
,
RAN
,
RANBP1
,
RB1
,
RELA
,
RELB
,
RRAS
,
MAP2K4
,
SLC2A1
,
SPI1
,
SRF
,
STAT5A
,
STAT5B
,
TBP
,
TCF3
,
TERT
,
TGFB1
,
TGFB2
,
TGFB3
,
TGFBR1
,
TGFBR2
,
TLN1
,
TNF
,
TNFRSF1A
,
TP53
,
VCAM1
,
VDAC1
,
VDAC2
,
VDAC3
,
WNT1
,
WNT2
,
WNT3
,
WNT5A
,
WNT6
,
WNT7A
,
WNT7B
,
WNT8A
,
WNT8B
,
WNT10B
,
WNT11
,
WNT2B
,
WNT9A
,
WNT9B
,
XBP1
,
XPO1
,
ZFP36
,
IL1R2
,
FZD5
,
FZD3
,
FOSL1
,
TRRAP
,
FZD1
,
FZD4
,
FZD6
,
FZD7
,
FZD8
,
FZD9
,
RANBP3
,
PIK3R3
,
IKBKG
,
CDC23
,
NRP1
,
KAT2B
,
CDC16
,
MAP3K14
,
CCNB2
,
BUB3
,
PTTG1
,
TBPL1
,
AKT3
,
APC2
,
ANAPC10
,
KAT5
,
POLD3
,
PTTG2
,
CHEK2
,
FZD10
,
RRAS2
,
MRAS
,
CRTC1
,
ANAPC2
,
ANAPC4
,
WNT16
,
ANAPC5
,
ANAPC7
,
ANAPC11
,
POLE3
,
WNT4
,
VAC14
,
POLE4
,
POLD4
,
ANAPC1
,
CRTC3
,
WNT10A
,
WNT5B
,
SLC25A31
,
TLN2
,
WNT3A
,
TP53INP1
,
TNFRSF13C
,
ADCY4
,
CRTC2
,
CDC26
,
TBPL2
,
