description
Human T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammatory diseases such as HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Expression of Tax, a viral regulatory protein is critical to the pathogenesis. Tax is a transcriptional co-factor that interfere several signaling pathways related to anti-apoptosis or cell proliferation. The modulation of the signaling by Tax involve its binding to transcription factors like CREB/ATF, NF-kappa B, SRF, and NFAT

external resources
NCBI:373901
KEGG:hsa05166
PUBMED:17446673
PUBMED:16436385
PUBMED:14686485
PUBMED:19861996
PUBMED:19092975
PUBMED:11325603
PUBMED:16155602
PUBMED:12910251
PUBMED:16155605
PUBMED:16036567
PUBMED:11244044
PUBMED:18702816
PUBMED:15569630
PUBMED:21114861
PUBMED:16155611
PUBMED:17384582
PUBMED:16155608
PUBMED:10602469
PUBMED:19014483
PUBMED:9325311

genes
ADCY1 , ADCY2 , ADCY3 , ADCY5 , ADCY6 , ADCY7 , ADCY8 , ADCY9 , AKT1 , AKT2 , SLC25A4 , SLC25A5 , SLC25A6 , APC , XIAP , ATF1 , ATF3 , ATF4 , ATM , ATR , BAX , CCND1 , BCL2L1 , BUB1B , TSPO , CALR , CANX , CCND2 , CCND3 , CD3D , CD3E , CD3G , CD40 , CDC20 , CDC27 , CDK4 , CDKN1A , CDKN2A , CDKN2B , CDKN2C , CHEK1 , CHUK , CREB1 , ATF2 , CREBBP , CREM , CSF2 , CTNNB1 , DLG1 , DVL1 , DVL2 , DVL3 , E2F1 , E2F2 , E2F3 , EGR1 , EGR2 , ELK1 , ELK4 , EP300 , ETS1 , ETS2 , FDPS , FOS , FZD2 , KAT2A , GPS2 , GSK3B , HLA-A , HLA-B , HLA-C , HLA-DMA , HLA-DMB , HLA-DOA , HLA-DOB , HLA-DPA1 , HLA-DPB1 , HLA-DQA1 , HLA-DQA2 , HLA-DQB1 , HLA-DRA , HLA-DRB1 , HLA-DRB5 , HLA-E , HLA-F , HLA-G , HRAS , ICAM1 , IKBKB , IL1R1 , IL2 , IL2RA , IL2RB , IL2RG , IL6 , IL15 , IL15RA , ITGAL , ITGB2 , JAK1 , JAK3 , JUN , KRAS , LCK , LTA , LTBR , MAD2L1 , SMAD2 , SMAD3 , SMAD4 , MAP3K1 , MAP3K3 , MSX1 , MSX2 , MYB , MYBL1 , MYBL2 , MYC , NFATC1 , NFATC2 , NFATC3 , NFATC4 , NFKB1 , NFKB2 , NFKBIA , NFYB , NRAS , PCNA , PDGFA , PDGFB , PDGFRA , PDGFRB , PIK3CA , PIK3CB , PIK3CD , PIK3R1 , PIK3R2 , POLB , POLD1 , POLD2 , POLE , POLE2 , PPP3CA , PPP3CB , PPP3CC , PPP3R1 , PPP3R2 , PRKACA , PRKACB , PRKACG , MAPK8 , RAN , RANBP1 , RB1 , RELA , RELB , RRAS , MAP2K4 , SLC2A1 , SPI1 , SRF , STAT5A , STAT5B , TBP , TCF3 , TERT , TGFB1 , TGFB2 , TGFB3 , TGFBR1 , TGFBR2 , TLN1 , TNF , TNFRSF1A , TP53 , VCAM1 , VDAC1 , VDAC2 , VDAC3 , WNT1 , WNT2 , WNT3 , WNT5A , WNT6 , WNT7A , WNT7B , WNT8A , WNT8B , WNT10B , WNT11 , WNT2B , WNT9A , WNT9B , XBP1 , XPO1 , ZFP36 , IL1R2 , FZD5 , FZD3 , FOSL1 , TRRAP , FZD1 , FZD4 , FZD6 , FZD7 , FZD8 , FZD9 , RANBP3 , PIK3R3 , IKBKG , CDC23 , NRP1 , KAT2B , CDC16 , MAP3K14 , CCNB2 , BUB3 , PTTG1 , TBPL1 , AKT3 , APC2 , ANAPC10 , KAT5 , POLD3 , PTTG2 , CHEK2 , FZD10 , RRAS2 , MRAS , CRTC1 , ANAPC2 , ANAPC4 , WNT16 , ANAPC5 , ANAPC7 , ANAPC11 , POLE3 , WNT4 , VAC14 , POLE4 , POLD4 , ANAPC1 , CRTC3 , WNT10A , WNT5B , SLC25A31 , TLN2 , WNT3A , TP53INP1 , TNFRSF13C , ADCY4 , CRTC2 , CDC26 , TBPL2 ,