description
The Fanconi anemia pathway is required for the efficient repair of damaged DNA, especially interstrand cross-links (ICLs). DNA ICL is directly recognized by FANCM and associated proteins, that recruit the FA core complex. The FA core complex monoubiquitinates FANCD2 and FANCI. The monoubiquitinated FANCD2/FANCI becomes an active form and interacts with a series of DNA repair proteins and facilitates downstream repair pathways. Fanconi anemia is caused by mutations in one of at least 13 FA genes and is characterized by congenital growth abnormalities, bone marrow failure and cancer predisposition

external resources
NCBI:377262
KEGG:hsa03460
PUBMED:19805513
PUBMED:18518821
PUBMED:18047734
PUBMED:20039786
PUBMED:21701511
PUBMED:20064461

genes
ATR , BLM , BRCA1 , BRCA2 , ERCC1 , ERCC4 , FANCA , FANCC , FANCD2 , FANCE , FANCB , FANCF , FANCG , HES1 , MLH1 , PMS2 , POLH , RAD51 , RAD51C , REV3L , RPA1 , RPA2 , RPA3 , TOP3A , USP1 , TOP3B , TELO2 , POLI , FAN1 , UBE2T , RPA4 , POLK , REV1 , FANCL , FANCI , WDR48 , FANCM , SLX1B , PALB2 , RMI1 , MUS81 , FAAP100 , BRIP1 , ATRIP , SLX4 , FAAP24 , RMI2 , EME1 , EME2 , CENPX , POLN , CENPS , SLX1A , CENPS-CORT ,