description
Gamma aminobutyric acid (GABA) is the most abundant inhibitory neurotransmitter in the mammalian central nervous system (CNS). When released in the synaptic cleft, GABA binds to three major classes of receptors: GABAA, GABAB, and GABAC receptors. GABAA and GABAC receptors are ionotropic and mediate fast GABA responses by triggering chloride channel openings, while GABAB receptors are metabotropic and mediate slower GABA responses by activating G-proteins and influencing second messenger systems. GABAA receptors, the major sites for fast inhibitory neurotransmission in the CNS, are regulated by phosphorylation mechanisms, affecting both their functional properties and their cell surface mobility and trafficking. GABA release by the presynaptic terminal is negatively regulated by GABAB autoreceptors, and is cleared from the extracellular space by GABA transporters (GATs) located either on the presynaptic terminal or neighboring glial cells

external resources
NCBI:377263
KEGG:hsa04727
PUBMED:21555068
PUBMED:20655485
PUBMED:16932937
PUBMED:17499108
PUBMED:12086709
PUBMED:20655481
PUBMED:21376567
PUBMED:19374920
PUBMED:17499109
PUBMED:10780899
PUBMED:16787421
PUBMED:15210304
PUBMED:18382465
PUBMED:12888801
PUBMED:9364667

genes
ABAT , ADCY1 , ADCY2 , ADCY3 , ADCY5 , ADCY6 , ADCY7 , ADCY8 , ADCY9 , CACNA1A , CACNA1B , CACNA1C , CACNA1D , CACNA1F , CACNA1S , GABBR1 , GABRA1 , GABRA2 , GABRA3 , GABRA4 , GABRA5 , GABRA6 , GABRB1 , GABRB2 , GABRB3 , GABRD , GABRE , GABRG1 , GABRG2 , GABRG3 , GABRP , GABRR1 , GABRR2 , GAD1 , GAD2 , GLS , GLUL , GNAI1 , GNAI2 , GNAI3 , GNAO1 , GNB1 , GNB2 , GNB3 , GNG3 , GNG4 , GNG5 , GNG7 , GNG10 , GNG11 , GNGT1 , GNGT2 , KCNJ6 , NSF , PLCL1 , PRKACA , PRKACB , PRKACG , PRKCA , PRKCB , PRKCG , SLC6A1 , SLC6A11 , SLC6A13 , SRC , HAP1 , GABBR2 , GPHN , GNB5 , SLC38A3 , GABARAP , GABARAPL2 , GABARAPL1 , GLS2 , GNG13 , GNG2 , SLC38A2 , GABRQ , GNG12 , SLC12A5 , GNB4 , TRAK2 , SLC38A1 , SLC38A5 , GNG8 , SLC32A1 , ADCY4 , GABRR3 ,