description
Legionellosis is a potentially fatal infectious disease caused by the bacterium Legionella pneumophila and other legionella species. Two distinct clinical and epidemiological syndromes are associated with Legionella species: Legionnaires' disease is the more severe form of the infection, which may involve pneumonia, and Pontiac fever is a milder respiratory illness. The pathogenesis of L. pneumophila is derived from its growth within lung macrophages. One of the L. pneumophila's type IV secretion systems, the Dot/Icm secretion system, is of critical importance for its ability to replicate and to cause disease. The Dot/Icm substrates modulate multiple host cell processes and in particular, redirect trafficking of the L. pneumophila phagosome and mediate its conversion into an ER-derived organelle competent for intracellular bacterial replication. L. pneumophila also manipulates host cell death and survival pathways in a way that allows continued intracellular replication

external resources
NCBI:469200
KEGG:hsa05134
PUBMED:19021631
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PUBMED:16495539
PUBMED:12427954

genes
APAF1 , ARF1 , BNIP3 , C3 , CASP1 , CASP3 , CASP7 , CASP8 , CASP9 , CD14 , CLK1 , CR1 , EEF1A1 , EEF1A2 , EEF1G , CXCL1 , CXCL2 , CXCL3 , HSF1 , HSPA1A , HSPA1B , HSPA1L , HSPA2 , HSPA6 , HSPA8 , HSPD1 , IL1B , IL6 , CXCL8 , IL12A , IL12B , IL18 , ITGAM , ITGB2 , MYD88 , NAIP , NFKB1 , NFKB2 , NFKBIA , RAB1A , RELA , TLR2 , TLR4 , TLR5 , TNF , VCP , HBS1L , BCL2L13 , PYCARD , SAR1B , CYCS , SAR1A , NLRC4 , RAB1B ,