description
Serotonin (5-Hydroxytryptamine, 5-HT) is a monoamine neurotransmitter that plays important roles in physiological functions such as learning and memory, emotion, sleep, pain, motor function and endocrine secretion, as well as in pathological states including abnormal mood and cognition. Once released from presynaptic axonal terminals, 5-HT binds to receptors, which have been divided into 7 subfamilies on the basis of conserved structures and signaling mechanisms. These families include the ionotropic 5-HT3 receptors and G-protein-coupled 5-HT receptors, the 5-HT1 (Gi /Go -coupled), 5-HT2(Gq-coupled), 5-HT4/6/7 (Gs-coupled) and 5-HT5 receptors. Presynaptically localized 5-HT1B receptors are thought to be the autoreceptors that suppress excess 5-HT release. 5-HT's actions are terminated by transporter- mediated reuptake into neurons, leading to catabolism by monoamine oxidase

external resources
NCBI:525336
KEGG:hsa04726
PUBMED:9658404
PUBMED:15034221
PUBMED:11043573
PUBMED:9651340
PUBMED:9542727
PUBMED:18676031
PUBMED:12543273
PUBMED:15710402
PUBMED:16826372
PUBMED:19545642
PUBMED:11916537
PUBMED:11701344
PUBMED:12676358
PUBMED:20561690
PUBMED:16896947

genes
ADCY5 , ALOX12 , ALOX5 , ALOX12B , ALOX15 , ALOX15B , APP , ARAF , BRAF , CACNA1A , CACNA1B , CACNA1C , CACNA1D , CACNA1F , CACNA1S , CASP3 , CYP2C19 , CYP2C8 , CYP2C9 , CYP2C18 , CYP2D6 , CYP2J2 , DDC , DUSP1 , GABRB1 , GABRB2 , GABRB3 , GNAI1 , GNAI2 , GNAI3 , GNAO1 , GNAQ , GNAS , GNB1 , GNB2 , GNB3 , GNG3 , GNG4 , GNG5 , GNG7 , GNG10 , GNG11 , GNGT1 , GNGT2 , HRAS , HTR1A , HTR1B , HTR1D , HTR1E , HTR1F , HTR2A , HTR2B , HTR2C , HTR3A , HTR4 , HTR5A , HTR6 , HTR7 , ITPR1 , ITPR2 , ITPR3 , KCND2 , KCNJ3 , KCNJ5 , KCNJ6 , KCNJ9 , KCNN2 , KRAS , MAOA , MAOB , NRAS , PLA2G4A , PLCB2 , PLCB3 , PLCB4 , PRKACA , PRKACB , PRKACG , PRKCA , PRKCB , PRKCG , MAPK1 , MAPK3 , MAP2K1 , PTGS1 , PTGS2 , RAF1 , SLC6A4 , SLC18A1 , SLC18A2 , TPH1 , TRPC1 , PLA2G4C , JMJD7-PLA2G4B , HTR3B , RAPGEF3 , GNB5 , PLCB1 , GNG13 , GNG2 , GNG12 , GNB4 , GNG8 , TPH2 , PLA2G4E , HTR3C , HTR3D , PLA2G4F , CYP4X1 , PLA2G4D , HTR3E , PLA2G4B ,