description
Endogenous cannabinoids (endocannabinoids) serve as retrograde messengers at synapses in various regions of the brain. The family of endocannabinoids includes at least five derivatives of arachidonic acid; the two best characterized are arachydonoyl ethanolamide (anandamide, AEA) and 2-arachydonoil glycerol (2AG). They are released from postsynaptic neurons upon postsynaptic depolarization and/or receptor activation. The released endocannabinoids then activate the CB1 receptors (CB1R) at presynaptic terminals and suppress the release of inhibitory transmitter GABA (depolarization-induced suppression of inhibition, DSI) or excitatory transmitter glutamate (depolarization-induced suppression of excitation, DSE) by inhibiting Ca2+ channels. Whereas DSI and DSE result in short-term synaptic plasticity, endocannabinoids also mediate long-term synaptic changes (eCB-LTD). Persistent activation of CB1 receptors over a period of minutes triggers eCB-LTD by a RIM1alpha-dependent mechanism

external resources
NCBI:537443
KEGG:hsa04723
PUBMED:16085309
PUBMED:18515270
PUBMED:15340387
PUBMED:17636069
PUBMED:17553427
PUBMED:17404373
PUBMED:19640475
PUBMED:21117095
PUBMED:18084639
PUBMED:21187849
PUBMED:18801434
PUBMED:14978245
PUBMED:21531987
PUBMED:19553483
PUBMED:19126760
PUBMED:17419048
PUBMED:18948642
PUBMED:16968947

genes
ADCY1 , ADCY2 , ADCY3 , ADCY5 , ADCY6 , ADCY7 , ADCY8 , ADCY9 , DAGLA , CACNA1A , CACNA1B , CACNA1C , CACNA1D , CACNA1F , CACNA1S , CNR1 , MAPK14 , FAAH , GABRA1 , GABRA2 , GABRA3 , GABRA4 , GABRA5 , GABRA6 , GABRB1 , GABRB2 , GABRB3 , GABRD , GABRE , GABRG1 , GABRG2 , GABRG3 , GABRP , GABRR1 , GABRR2 , GNAI1 , GNAI2 , GNAI3 , GNAO1 , GNAQ , GNB1 , GNB2 , GNB3 , GNG3 , GNG4 , GNG5 , GNG7 , GNG10 , GNG11 , GNGT1 , GNGT2 , GRIA1 , GRIA2 , GRIA3 , GRIA4 , GRM1 , GRM5 , ITPR1 , ITPR2 , ITPR3 , KCNJ3 , KCNJ5 , KCNJ6 , KCNJ9 , PLCB2 , PLCB3 , PLCB4 , PRKACA , PRKACB , PRKACG , PRKCA , PRKCB , PRKCG , MAPK1 , MAPK3 , MAPK8 , MAPK11 , MAPK9 , MAPK10 , MAPK13 , PTGS2 , MAPK12 , GNB5 , MGLL , RIMS1 , PLCB1 , GNG13 , GNG2 , GABRQ , GNG12 , SLC17A7 , SLC17A6 , ABHD6 , GNB4 , GNG8 , SLC32A1 , ADCY4 , GABRR3 , DAGLB , NAPEPLD , SLC17A8 ,