description
: INOSITOL-1-4-5-TRISPHOSPHATE is a secondary messenger molecule used in signal transduction and lipid signaling. It mediates the biological response of a large number of hormones and neurotransmitters in target cells by regulating calcium release from intracellular stores. : INOSITOL-1-4-5-TRISPHOSPHATE is synthesized by hydrolysis of : PHOSPHATIDYL-MYO-INOSITOL-45-BISPHOSPHA "phosphatidylinositol 4,5-bisphosphate" (PIP2), a phospholipid that is located in the plasma membrane, by the action of phospholipase C, as described in : PWY-6351. Once formed, the levels of : INOSITOL-1-4-5-TRISPHOSPHATE are tightly regulated by two mechanisms. In the first mechanism, which is described in this pathway, the compound is dephosphorylated in three successive steps, via : INOSITOL-1-4-BISPHOSPHATE and : D-MYO-INOSITOL-4-PHOSPHATE , providing : MYO-INOSITOL that can be recycled to the plasma membrane as : L-1-phosphatidyl-inositols "phosphatidylinositol". In the second mechanism, : INOSITOL-1-4-5-TRISPHOSPHATE is phosphorylated further to generate additional phosphoinositol compounds, many of which play key roles in various cellular processes (see : PWY-6364)

external resources
NCBI:545327
BIOCYC:HUMAN_PWY-6363
PUBMED:6285891
PUBMED:6095097

genes
IMPA1 , IMPA2 , INPP1 , INPP5A , INPP5B , INPPL1 , OCRL , SYNJ1 , SYNJ2 , INPP5F , INPP5J , INPP5K , IMPAD1 ,