description
Drug addiction is a chronic, relapsing disorder in which compulsive drug-seeking and drug-taking behavior persists despite serious negative consequences.There is strong evidence that the dopaminergic system that projects from the ventral tegmental area (VTA) of the midbrain to the nucleus accumbens (NAc), and to other forebrain sites, is the major substrate of reward and reinforcement for both natural rewards and addictive drugs. Cocaine binds strongly to the dopamine-reuptake transporter, preventing the reuptake of dopamine into the nerve terminal. Because of this blocking effect, dopamine remains at high concentrations in the synapse and continues to affect adjacent neurons, producing the characteristic cocaine "high." Activated D1 receptor activates the PKA signaling pathway, and this pathway plays a critical role in mediating the behavioral responses to cocaine administration. Cocaine-induced neuroadaptations, including dopamine depletion, may underlie craving and hedonic dysregulation

external resources
NCBI:546258
KEGG:hsa05030
PUBMED:15091342
PUBMED:16278489
PUBMED:14566342
PUBMED:12064476
PUBMED:16251986
PUBMED:18440072
PUBMED:19403004
PUBMED:11595774
PUBMED:11268215
PUBMED:15582154
PUBMED:12818179
PUBMED:14746512
PUBMED:10234039

genes
ADCY5 , ATF4 , BDNF , CDK5 , CREB1 , ATF2 , ATF6B , DDC , DLG4 , DRD1 , DRD2 , FOSB , GNAI1 , GNAI2 , GNAI3 , GNAS , GRIA2 , GRIN1 , GRIN2A , GRIN2B , GRIN2C , GRIN2D , GRM2 , GRM3 , JUN , MAOA , MAOB , NFKB1 , PDYN , PRKACA , PRKACB , PRKACG , RELA , SLC6A3 , SLC18A1 , SLC18A2 , TH , RGS9 , CDK5R1 , CREB5 , CREB3 , GPSM1 , CREB3L2 , PPP1R1B , CREB3L3 , CREB3L1 , GRIN3A , GRIN3B , CREB3L4 ,