description
Nuclear factor-kappa B (NF-kappa B) is the generic name of a family of transcription factors that function as dimers and regulate genes involved in immunity, inflammation and cell survival. There are several pathways leading to NF-kappa B-activation. The canonical pathway is induced by tumour necrosis factor-alpha (TNF-alpha), interleukin-1 (IL-1) or byproducts of bacterial and viral infections. This pathway relies on IKK- mediated IkappaB-alpha phosphorylation on Ser32 and 36, leading to its degradation, which allows the p50/p65 NF-kappa B dimer to enter the nucleus and activate gene transcription. Atypical pathways are IKK-independent and rely on phosphorylation of IkappaB-alpha on Tyr42 or on Ser residues in IkappaB-alpha PEST domain. The non-canonical pathway is triggered by particular members of the TNFR superfamily, such as lymphotoxin-beta (LT-beta) or BAFF. It involves NIK and IKK-alpha-mediated p100 phosphorylation and processing to p52, resulting in nuclear translocation of p52/RelB heterodimers
external resources
NCBI:634527
KEGG:hsa04064
PUBMED:22119011
PUBMED:16264088
PUBMED:21187855
PUBMED:15546385
PUBMED:17607554
PUBMED:21135871
PUBMED:16984817
PUBMED:17047224
PUBMED:19203223
PUBMED:20300215
PUBMED:14657271
PUBMED:17431096
PUBMED:15134788
PUBMED:16356770
PUBMED:21772278
PUBMED:12654254
PUBMED:22390971
PUBMED:22017435
PUBMED:17183360
PUBMED:21173796
PUBMED:15905862
PUBMED:19302050
PUBMED:17098202
PUBMED:21872579
PUBMED:22152226
PUBMED:18613837
PUBMED:19489733
PUBMED:11875461
PUBMED:19726767
PUBMED:22017430
PUBMED:21232019
PUBMED:18832076
genes
PARP1
,
BIRC2
,
BIRC3
,
XIAP
,
ATM
,
BCL2
,
BCL2A1
,
BCL2L1
,
BTK
,
CD14
,
CD40
,
CD40LG
,
CHUK
,
CSNK2A1
,
CSNK2A2
,
CSNK2B
,
CXCL2
,
ICAM1
,
IKBKB
,
IL1B
,
IL1R1
,
CXCL8
,
IRAK1
,
LBP
,
LCK
,
LTA
,
LTB
,
LTBR
,
LYN
,
MYD88
,
GADD45B
,
NFKB1
,
NFKB2
,
NFKBIA
,
PLAU
,
PLCG1
,
PLCG2
,
PRKCB
,
PRKCQ
,
PTGS2
,
RELA
,
RELB
,
CCL4
,
CCL13
,
CCL19
,
CCL21
,
CXCL12
,
SYK
,
MAP3K7
,
TLR4
,
TNF
,
TNFAIP3
,
TNFRSF1A
,
TRAF1
,
TRAF2
,
TRAF3
,
TRAF5
,
TRAF6
,
UBE2I
,
VCAM1
,
ZAP70
,
TRIM25
,
IKBKG
,
TNFSF11
,
TRADD
,
RIPK1
,
TNFSF14
,
TNFRSF11A
,
CFLAR
,
BCL10
,
MAP3K14
,
CCL4L2
,
TAB1
,
TNFSF13B
,
MALT1
,
ERC1
,
TAB2
,
DDX58
,
LY96
,
LAT
,
BLNK
,
CARD10
,
IRAK4
,
PIAS4
,
PIDD1
,
CARD14
,
CARD11
,
TIRAP
,
TNFRSF13C
,
TICAM1
,
TAB3
,
CSNK2A3
,
TICAM2
,
CCL4L1
,