description
Nuclear factor-kappa B (NF-kappa B) is the generic name of a family of transcription factors that function as dimers and regulate genes involved in immunity, inflammation and cell survival. There are several pathways leading to NF-kappa B-activation. The canonical pathway is induced by tumour necrosis factor-alpha (TNF-alpha), interleukin-1 (IL-1) or byproducts of bacterial and viral infections. This pathway relies on IKK- mediated IkappaB-alpha phosphorylation on Ser32 and 36, leading to its degradation, which allows the p50/p65 NF-kappa B dimer to enter the nucleus and activate gene transcription. Atypical pathways are IKK-independent and rely on phosphorylation of IkappaB-alpha on Tyr42 or on Ser residues in IkappaB-alpha PEST domain. The non-canonical pathway is triggered by particular members of the TNFR superfamily, such as lymphotoxin-beta (LT-beta) or BAFF. It involves NIK and IKK-alpha-mediated p100 phosphorylation and processing to p52, resulting in nuclear translocation of p52/RelB heterodimers

external resources
NCBI:634527
KEGG:hsa04064
PUBMED:22119011
PUBMED:16264088
PUBMED:21187855
PUBMED:15546385
PUBMED:17607554
PUBMED:21135871
PUBMED:16984817
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PUBMED:21772278
PUBMED:12654254
PUBMED:22390971
PUBMED:22017435
PUBMED:17183360
PUBMED:21173796
PUBMED:15905862
PUBMED:19302050
PUBMED:17098202
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PUBMED:22152226
PUBMED:18613837
PUBMED:19489733
PUBMED:11875461
PUBMED:19726767
PUBMED:22017430
PUBMED:21232019
PUBMED:18832076

genes
PARP1 , BIRC2 , BIRC3 , XIAP , ATM , BCL2 , BCL2A1 , BCL2L1 , BTK , CD14 , CD40 , CD40LG , CHUK , CSNK2A1 , CSNK2A2 , CSNK2B , CXCL2 , ICAM1 , IKBKB , IL1B , IL1R1 , CXCL8 , IRAK1 , LBP , LCK , LTA , LTB , LTBR , LYN , MYD88 , GADD45B , NFKB1 , NFKB2 , NFKBIA , PLAU , PLCG1 , PLCG2 , PRKCB , PRKCQ , PTGS2 , RELA , RELB , CCL4 , CCL13 , CCL19 , CCL21 , CXCL12 , SYK , MAP3K7 , TLR4 , TNF , TNFAIP3 , TNFRSF1A , TRAF1 , TRAF2 , TRAF3 , TRAF5 , TRAF6 , UBE2I , VCAM1 , ZAP70 , TRIM25 , IKBKG , TNFSF11 , TRADD , RIPK1 , TNFSF14 , TNFRSF11A , CFLAR , BCL10 , MAP3K14 , CCL4L2 , TAB1 , TNFSF13B , MALT1 , ERC1 , TAB2 , DDX58 , LY96 , LAT , BLNK , CARD10 , IRAK4 , PIAS4 , PIDD1 , CARD14 , CARD11 , TIRAP , TNFRSF13C , TICAM1 , TAB3 , CSNK2A3 , TICAM2 , CCL4L1 ,