description
Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that functions as a master regulator of oxygen homeostasis. It consists of two subunits: an inducibly-expressed HIF-1alpha subunit and a constitutively-expressed HIF-1beta subunit. Under normoxia, HIF-1 alpha undergoes hydroxylation at specific prolyl residues which leads to an immediate ubiquitination and subsequent proteasomal degradation of the subunit. In contrast, under hypoxia, HIF-1 alpha subunit becomes stable and interacts with coactivators such as p300/CBP to modulate its transcriptional activity. Eventually, HIF-1 acts as a master regulator of numerous hypoxia-inducible genes under hypoxic conditions. The target genes of HIF-1 encode proteins that increase O2 delivery and mediate adaptive responses to O2 deprivation. Despite its name, HIF-1 is induced not only in response to reduced oxygen availability but also by other stimulants, such as nitric oxide, or various growth factors

external resources
NCBI:695200
KEGG:hsa04066
PUBMED:11902584
PUBMED:20965423
PUBMED:20679415
PUBMED:15031665
PUBMED:18259201
PUBMED:22205687
PUBMED:19364912
PUBMED:19147540
PUBMED:15448722
PUBMED:16234508
PUBMED:18505681
PUBMED:20836033
PUBMED:19861159
PUBMED:17955264
PUBMED:22562152

genes
AKT1 , AKT2 , ALDOA , ANGPT1 , ANGPT2 , ARNT , BCL2 , CAMK2A , CAMK2B , CAMK2D , CAMK2G , CDKN1A , CDKN1B , CREBBP , CYBB , EDN1 , EGF , EGFR , EIF4E , EIF4EBP1 , ENO1 , ENO2 , ENO3 , EP300 , EPO , ERBB2 , FLT1 , MTOR , GAPDH , MKNK2 , HIF1A , HK1 , HK2 , HK3 , HMOX1 , IFNG , IFNGR1 , IFNGR2 , IGF1 , IGF1R , IL6 , IL6R , INS , INSR , LDHA , LTBR , NFKB1 , NOS2 , NOS3 , NPPA , SERPINE1 , PDHA1 , PDHA2 , PDHB , PDK1 , PFKFB3 , PFKL , PGK1 , PIK3CA , PIK3CB , PIK3CD , PIK3R1 , PIK3R2 , PLCG1 , PLCG2 , PRKCA , PRKCB , PRKCG , MAPK1 , MAPK3 , MAP2K1 , MAP2K2 , RELA , RPS6 , RPS6KB1 , RPS6KB2 , SLC2A1 , STAT3 , ELOC , ELOB , TEK , TF , TFRC , TIMP1 , TLR4 , VEGFA , VHL , CUL2 , PIK3R3 , MKNK1 , EIF4E2 , RBX1 , AKT3 , NOX1 , NOX3 , ANGPT4 , EGLN1 , HKDC1 , EGLN2 , EGLN3 , EIF4E1B ,