description
Hippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor Salvador and LATS1 and LATS2. In response to high cell densities, activated LATS1/2 phosphorylates the transcriptional coactivators YAP and TAZ, promoting its cytoplasmic localization, leading to cell apoptosis and restricting organ size overgrowth. When the Hippo pathway is inactivated at low cell density, YAP/TAZ translocates into the nucleus to bind to the transcription enhancer factor (TEAD/TEF) family of transcriptional factors to promote cell growth and proliferation. YAP/TAZ also interacts with other transcriptional factors or signaling molecules, by which Hippo pathway-mediated processes are interconnected with those of other key signaling cascades, such as those mediated by TGF-beta and Wnt growth factors

external resources
NCBI:749777
KEGG:hsa04390
PUBMED:18955139
PUBMED:20439427
PUBMED:20951342
PUBMED:21138973
PUBMED:18328423
PUBMED:21324984
PUBMED:23034192
PUBMED:21808241
PUBMED:17975546
PUBMED:22750148
PUBMED:21084559
PUBMED:19846288
PUBMED:22895435
PUBMED:22683405
PUBMED:22658639
PUBMED:22153608
PUBMED:20945341
PUBMED:22830020
PUBMED:21874053
PUBMED:21376238

genes
ACTB , ACTG1 , AFP , AMH , APC , BIRC2 , BIRC5 , AREG , CCND1 , BMP2 , BMP4 , BMP5 , BMP6 , BMP7 , BMP8B , BMPR1A , BMPR1B , BMPR2 , CCND2 , CCND3 , CDH1 , CSNK1D , CSNK1E , CTGF , CTNNA1 , CTNNA2 , CTNNB1 , DLG1 , DLG2 , DLG3 , DLG4 , DVL1 , DVL2 , DVL3 , FGF1 , FZD2 , GLI2 , GSK3B , ID1 , ID2 , ITGB2 , LLGL2 , LLGL1 , SMAD1 , SMAD2 , SMAD3 , SMAD4 , SMAD7 , MYC , NF2 , SERPINE1 , PPP1CA , PPP1CB , PPP1CC , PPP2CA , PPP2CB , PPP2R1A , PPP2R1B , PPP2R2A , PPP2R2B , PPP2R2C , PRKCI , PRKCZ , SNAI2 , SOX2 , STK3 , TCF7 , TCF7L2 , TEAD1 , TEAD4 , TEAD3 , TGFB1 , TGFB2 , TGFB3 , TGFBR1 , TGFBR2 , TP53BP2 , TP73 , WNT1 , WNT2 , WNT3 , WNT5A , WNT6 , WNT7A , WNT7B , WNT8A , WNT8B , WNT10B , WNT11 , WNT2B , WNT9A , WNT9B , YWHAB , YWHAE , YWHAG , YWHAH , YWHAZ , FZD5 , FZD3 , GDF5 , AXIN1 , AXIN2 , FZD1 , FZD4 , FZD6 , FZD7 , FZD8 , FZD9 , TEAD2 , BTRC , LIMD1 , LATS1 , PATJ , APC2 , YAP1 , YWHAQ , RASSF1 , FZD10 , WWC1 , FBXW11 , CRB1 , SCRIB , WWTR1 , LATS2 , BBC3 , CTNNA3 , PARD6A , LEF1 , WNT16 , WNT4 , MOB1A , PPP2R2D , PARD3 , SAV1 , MPP5 , FRMD1 , WNT10A , WNT5B , TCF7L1 , PARD6G , PARD6B , AJUBA , NKD1 , WNT3A , MOB1B , FRMD6 , WTIP , GDF7 , AMOT , RASSF6 , CRB2 , BMP8A , GDF6 ,