description
The ovarian steroids, 17-beta estradiol (E2) and progesterone (P4), are critical for normal uterine function, establishment and maintenance of pregnancy, and mammary gland development. Furthermore, the local effects that are essential for normal ovarian physiology are dependent on the endocrine, paracrine, and autocrine actions of E2, P4, and androgens. In most mammals (including humans and mice), ovarian steroidogenesis occurs according to the two-cell/two-gonadotropin theory. This theory describes how granulosa and theca cells work together to make the ovarian steroids. Theca cells respond to LH signaling by increasing the expression of enzymes necessary for the conversion of cholesterol to androgens, such as androstenedione (A) and testosterone (T). Granulosa cells respond to FSH signaling by increasing the expression of enzymes necessary for the conversion of theca-derived androgens into estrogens (E2 and estrone)

external resources
NCBI:790011
KEGG:hsa04913
PUBMED:11883103
PUBMED:11408113
PUBMED:16603089
PUBMED:15831519
PUBMED:11447221
PUBMED:20628033
PUBMED:10630400
PUBMED:18440223
PUBMED:20937107
PUBMED:11704115
PUBMED:17003287
PUBMED:17008391
PUBMED:15541573
PUBMED:21862696
PUBMED:16414178
PUBMED:14769828

genes
ADCY1 , ADCY2 , ADCY3 , ADCY5 , ADCY6 , ADCY7 , ADCY8 , ADCY9 , ALOX5 , BMP6 , SCARB1 , CGA , CYP1A1 , CYP1B1 , CYP2J2 , CYP11A1 , CYP17A1 , CYP19A1 , FSHB , FSHR , GDF9 , GNAS , HSD3B1 , HSD3B2 , HSD17B1 , HSD17B2 , IGF1 , IGF1R , INS , INSR , LDLR , LHB , LHCGR , PLA2G4A , PRKACA , PRKACB , PRKACG , PTGS2 , STAR , PLA2G4C , AKR1C3 , JMJD7-PLA2G4B , BMP15 , ACOT2 , HSD17B7 , PLA2G4E , ADCY4 , PLA2G4F , PLA2G4D , PLA2G4B ,