description
Prolactin (PRL) is a polypeptide hormone known to be involved in a wide range of biological functions including osmoregulation, lactation, reproduction, growth and development, endocrinology and metabolism, brain and behavior, and immunomodulation. PRL mediates its action through PRLR, a transmembrane protein of the hematopoietin cytokine receptor superfamily. At the protein level, the long PRLR isoform (long-R) and several short PRLR isoforms (short-R) have been detected. Acting through the long-R, PRL activates many signaling cascades including Jak2/Stat, the major cascade, Src kinase, phosphatidylinositol-3-kinase (PI3K)/AKT, and mitogen-activated protein kinase (MAPK) pathways. PRL cannot activate Jak2/Stat5 through the short-R, but can activate pathways including MAPK and PI3K pathways

external resources
NCBI:814182
KEGG:hsa04917
PUBMED:17519353
PUBMED:17535875
PUBMED:20149678
PUBMED:12670737
PUBMED:17307904
PUBMED:18601698
PUBMED:17975019
PUBMED:16231422
PUBMED:18219564
PUBMED:9475379
PUBMED:16677418
PUBMED:9626554
PUBMED:21664429
PUBMED:11606470

genes
AKT1 , AKT2 , CCND1 , CCND2 , CGA , CISH , MAPK14 , CSN2 , CYP17A1 , ELF5 , ESR1 , ESR2 , FOXO3 , FOS , GALT , GCK , GRB2 , GSK3B , HRAS , INS , IRF1 , JAK2 , KRAS , LHB , LHCGR , NFKB1 , NRAS , PIK3CA , PIK3CB , PIK3CD , PIK3R1 , PIK3R2 , MAPK1 , MAPK3 , MAPK8 , MAPK11 , MAPK9 , MAPK10 , MAPK13 , MAP2K1 , MAP2K2 , PRL , PRLR , RAF1 , RELA , MAPK12 , SHC1 , SLC2A2 , SOS1 , SOS2 , SRC , STAT1 , STAT3 , STAT5A , STAT5B , TH , PIK3R3 , TNFSF11 , SOCS1 , TNFRSF11A , SOCS2 , SOCS3 , SOCS6 , SOCS5 , AKT3 , SHC2 , SOCS7 , SHC3 , SOCS4 , SHC4 ,