description
MicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or the inhibition of protein translation. Using high-throughput profiling, dysregulation of miRNAs has been widely observed in different stages of cancer. The upregulation (overexpression) of specific miRNAs could lead to the repression of tumor suppressor gene expression, and conversely the downregulation of specific miRNAs could result in an increase of oncogene expression; both these situations induce subsequent malignant effects on cell proliferation, differentiation, and apoptosis that lead to tumor growth and progress. The miRNA signatures of cancer observed in various studies differ significantly. These inconsistencies occur due to the differences in the study populations and methodologies used. This pathway map shows the summarized results from various studies in 9 cancers, each of which is presented in a review article

external resources
NCBI:852705
KEGG:hsa05206
PUBMED:23075324
PUBMED:21742789
PUBMED:22351564
PUBMED:18817506
PUBMED:22345301
PUBMED:21402473
PUBMED:22926415
PUBMED:23165235
PUBMED:19630570
PUBMED:21565290
PUBMED:23091478
PUBMED:23462054
PUBMED:23316212
PUBMED:19773200
PUBMED:22035854
PUBMED:20221895
PUBMED:20345848
PUBMED:22580099
PUBMED:20128019

genes
ABL1 , APC , RHOA , ATM , BAK1 , CCND1 , BCL2 , BCL2L2 , BMI1 , BMPR2 , BRCA1 , CASP3 , CCND2 , CCNE1 , CCNG1 , CD44 , CDC25A , CDC25B , CDC25C , CDK6 , CDKN1A , CDKN1B , CDKN2A , CREBBP , CRK , CRKL , CYP1B1 , CYP24A1 , DNMT1 , DNMT3A , DNMT3B , E2F1 , E2F2 , E2F3 , EFNA3 , EGFR , EP300 , ERBB2 , ERBB3 , EZH2 , FGFR3 , MTOR , GLS , GRB2 , HDAC1 , HMOX1 , HNRNPK , HOXD10 , HRAS , TNC , IKBKB , IRS1 , ITGA5 , ITGB3 , KRAS , STMN1 , MARCKS , MCL1 , MDM2 , MDM4 , MET , MMP9 , MMP16 , ABCC1 , MYC , NFKB1 , NOTCH1 , NOTCH2 , NOTCH3 , NOTCH4 , NRAS , PDGFA , PDGFB , PDGFRA , PDGFRB , ABCB1 , SERPINB5 , PIK3CA , PIM1 , PIK3R2 , PLAU , PLCG1 , PLCG2 , PRKCA , PRKCB , PRKCE , PRKCG , MAPK1 , MAPK7 , MAP2K1 , MAP2K2 , PTEN , PTGS2 , RAF1 , RDX , ROCK1 , SHC1 , SLC7A1 , FSCN1 , SOS1 , SOS2 , SOX4 , ST14 , STAT3 , ZEB1 , TGFB2 , THBS1 , TIMP3 , TNR , TNXB , TP53 , TPM1 , UBE2I , VEGFA , EZR , VIM , WNT3 , FZD3 , HMGA2 , RECK , TP63 , SOCS1 , IRS2 , CCNE2 , RPS6KA5 , KIF23 , HDAC4 , ZEB2 , BCL2L11 , SPRY2 , APC2 , PAK4 , IGF2BP1 , RASSF1 , DICER1 , SIRT1 , ZFPM2 , FOXP1 , GLS2 , PDCD4 , DDIT4 , RPTOR , TNN , SLC45A3 , WNT3A , BMF , CDCA5 , TRIM71 , SHC4 , MIRLET7A1 , MIRLET7A2 , MIRLET7A3 , MIRLET7B , MIRLET7C , MIRLET7D , MIRLET7E , MIRLET7F1 , MIRLET7F2 , MIRLET7G , MIRLET7I , MIR100 , MIR101-1 , MIR101-2 , MIR103A1 , MIR103A2 , MIR106B , MIR107 , MIR10A , MIR10B , MIR1-1 , MIR1-2 , MIR122 , MIR124-1 , MIR124-2 , MIR124-3 , MIR125A , MIR125B1 , MIR125B2 , MIR126 , MIR128-1 , MIR128-2 , MIR129-1 , MIR129-2 , MIR133A1 , MIR133A2 , MIR135A1 , MIR135A2 , MIR137 , MIR141 , MIR143 , MIR145 , MIR146A , MIR150 , MIR152 , MIR155 , MIR15A , MIR15B , MIR16-1 , MIR16-2 , MIR17 , MIR18A , MIR181A2 , MIR181B1 , MIR181B2 , MIR181C , MIR183 , MIR192 , MIR194-1 , MIR194-2 , MIR195 , MIR199A1 , MIR199A2 , MIR199B , MIR19A , MIR19B1 , MIR19B2 , MIR20A , MIR200A , MIR200B , MIR200C , MIR203A , MIR205 , MIR206 , MIR21 , MIR210 , MIR181A1 , MIR214 , MIR215 , MIR221 , MIR222 , MIR223 , MIR224 , MIR23A , MIR23B , MIR25 , MIR26A1 , MIR26A2 , MIR26B , MIR27A , MIR27B , MIR28 , MIR29A , MIR29B1 , MIR29B2 , MIR29C , MIR30A , MIR30B , MIR30C1 , MIR30C2 , MIR30D , MIR30E , MIR31 , MIR32 , MIR34A , MIR34B , MIR34C , MIR7-1 , MIR7-2 , MIR7-3 , MIR9-1 , MIR9-2 , MIR92A1 , MIR92A2 , MIR9-3 , MIR96 , MIR99A , MIR133B , MIR135B , MIR324 , MIR326 , MIR330 , MIR331 , MIR335 , MIR342 , MIR345 , MIR373 , MIR375 , MIR423 , MIR449A , MIR363 , MIR451A , MIR494 , MIR193B , MIR181D , MIR520E , MIR520A , MIR520B , MIR520C , MIR520G , MIR520H , MIR483 , MIR602 , MIR615 , MIR625 , MIR103B1 , MIR103B2 , MIR23C , COMMD3-BMI1 , MIR203B ,