description
The Ras proteins are GTPases that function as molecular switches for signaling pathways regulating cell proliferation, survival, growth, migration, differentiation or cytoskeletal dynamism. Ras proteins transduce signals from extracellular growth factors by cycling between inactive GDP-bound and active GTP-bound states. The exchange of GTP for GDP on RAS is regulated by guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs). Activated RAS (RAS-GTP) regulates multiple cellular functions through effectors including Raf, phosphatidylinositol 3-kinase (PI3K) and Ral guanine nucleotide-dissociation stimulator (RALGDS)

external resources
NCBI:868085
KEGG:hsa04014
PUBMED:23506953
PUBMED:18437264
PUBMED:15062121
PUBMED:22189424
PUBMED:22233291
PUBMED:12778136
PUBMED:11313946
PUBMED:17428555
PUBMED:19091743
PUBMED:18568040
PUBMED:20420946
PUBMED:12217381
PUBMED:14663478
PUBMED:21686117
PUBMED:12642680
PUBMED:21196257
PUBMED:16869784
PUBMED:21111786
PUBMED:16966426
PUBMED:10712923
PUBMED:22020205
PUBMED:17384584
PUBMED:15572660
PUBMED:18413813

genes
ABL1 , ABL2 , AKT1 , AKT2 , ANGPT1 , ANGPT2 , FASLG , ARF6 , RHOA , BAD , BCL2L1 , CALM1 , CALM2 , CALM3 , CALML3 , CDC42 , CHUK , CSF1 , CSF1R , EFNA1 , EFNA2 , EFNA3 , EFNA4 , EFNA5 , EGF , EGFR , EPHA2 , ELK1 , ETS1 , ETS2 , FGF1 , FGF2 , FGF3 , FGF4 , FGF5 , FGF6 , FGF7 , FGF8 , FGF9 , FGF10 , FGF11 , FGF12 , FGF13 , FGF14 , FGFR1 , FGFR3 , FGFR2 , FGFR4 , VEGFD , FLT1 , FLT4 , GAB1 , GNB1 , GNB2 , GNB3 , GNG3 , GNG4 , GNG5 , GNG7 , GNG10 , GNG11 , GNGT1 , GNGT2 , GRB2 , GRIN1 , GRIN2A , GRIN2B , HGF , HRAS , HTR7 , IGF1 , IGF1R , IKBKB , INS , INSR , KDR , KIT , KRAS , MET , KITLG , AFDN , FOXO4 , NF1 , NFKB1 , NGF , NGFR , NRAS , PAK1 , PAK2 , PAK3 , PDGFA , PDGFB , PDGFRA , PDGFRB , PGF , PIK3CA , PIK3CB , PIK3CD , PIK3R1 , PIK3R2 , PLA2G1B , PLA2G2A , PLA2G4A , PLA2G5 , PLCG1 , PLCG2 , PLD1 , PLD2 , PRKACA , PRKACB , PRKACG , PRKCA , PRKCB , PRKCG , MAPK1 , MAPK3 , MAPK8 , MAPK9 , MAPK10 , MAP2K1 , MAP2K2 , PTPN11 , RGL2 , RAB5A , RAB5B , RAB5C , RAC1 , RAC2 , RAC3 , RAF1 , RALA , RALB , RALGDS , RAP1A , RAP1B , RASA1 , RASA2 , RASGRF1 , RASGRF2 , REL , RELA , RRAS , SHC1 , SOS1 , SOS2 , STK4 , TEK , TIAM1 , VEGFA , VEGFB , VEGFC , ZAP70 , SHOC2 , FGF23 , BRAP , PLA2G6 , PLA2G10 , RASAL1 , PIK3R3 , IKBKG , PLA2G4C , JMJD7-PLA2G4B , FGF18 , FGF17 , FGF16 , SYNGAP1 , KSR1 , RASAL2 , RIN1 , RAPGEF5 , GAB2 , FGF19 , AKT3 , RASGRP1 , RASA4 , RASGRP2 , PAK4 , GNB5 , RALBP1 , PLA2G16 , RASSF1 , RRAS2 , MRAS , RASA3 , RGL1 , SHC2 , RASGRP3 , PLA2G2D , FGF20 , FGF21 , FGF22 , LAT , TBK1 , PLA2G2E , PLA2G3 , PLCE1 , PLA1A , ANGPT4 , GNG13 , CALML5 , SHC3 , GNG2 , EXOC2 , GNG12 , PDGFC , PAK6 , PAK5 , GNB4 , PLA2G2F , RASAL3 , PDGFD , PLA2G12A , RASSF5 , PLA2G12B , CALML4 , GNG8 , RASGRP4 , PLA2G4E , CALML6 , PLA2G4F , KSR2 , PLA2G4D , PLA2G2C , SHC4 , PLA2G4B , RASA4B ,