description
Rap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an active GTP-bound conformation. A variety of extracellular signals control this cycle through the regulation of several unique guanine nucleotide exchange factors (GEFs) and GTPase activating proteins (GAPs). Rap1 plays a dominant role in the control of cell-cell and cell-matrix interactions by regulating the function of integrins and other adhesion molecules in various cell types. Rap1 also regulates MAP kinase (MAPK) activity in a manner highly dependent on the context of cell types

external resources
NCBI:868086
KEGG:hsa04015
PUBMED:17624944
PUBMED:12351703
PUBMED:10579920
PUBMED:19159611
PUBMED:18363565
PUBMED:12765839
PUBMED:12508104
PUBMED:11331911
PUBMED:17182900
PUBMED:15803158
PUBMED:19615876
PUBMED:21402149
PUBMED:17624948
PUBMED:17383543
PUBMED:14607972
PUBMED:15780587
PUBMED:19710505

genes
ACTB , ACTG1 , ADCY1 , ADCY2 , ADCY3 , ADCY5 , ADCY6 , ADCY7 , ADCY8 , ADCY9 , ADORA2A , ADORA2B , AKT1 , AKT2 , ANGPT1 , ANGPT2 , RHOA , BRAF , CALM1 , CALM2 , CALM3 , CALML3 , KRIT1 , CDC42 , CDH1 , CNR1 , CRK , CRKL , MAPK14 , CSF1 , CSF1R , CTNNB1 , CTNND1 , DRD2 , LPAR1 , EFNA1 , EFNA2 , EFNA3 , EFNA4 , EFNA5 , EGF , EGFR , EPHA2 , F2R , FGF1 , FGF2 , FGF3 , FGF4 , FGF5 , FGF6 , FGF7 , FGF8 , FGF9 , FGF10 , FGF11 , FGF12 , FGF13 , FGF14 , FGFR1 , FGFR3 , FGFR2 , FGFR4 , VEGFD , FLT1 , FLT4 , FPR1 , FYB1 , GNAI1 , GNAI2 , GNAI3 , GNAO1 , GNAQ , GNAS , LPAR4 , RAPGEF1 , GRIN1 , GRIN2A , GRIN2B , HGF , HRAS , ID1 , IGF1 , IGF1R , INS , INSR , ITGA2B , ITGAL , ITGAM , ITGB1 , ITGB2 , ITGB3 , KDR , KIT , KRAS , LCP2 , MET , KITLG , AFDN , NGF , NGFR , NRAS , P2RY1 , PDGFA , PDGFB , PDGFRA , PDGFRB , PFN1 , PFN2 , PGF , PIK3CA , PIK3CB , PIK3CD , PIK3R1 , PIK3R2 , PLCB2 , PLCB3 , PLCB4 , PLCG1 , PRKCA , PRKCB , PRKCG , PRKCI , PRKD1 , PRKCZ , MAPK1 , MAPK3 , MAPK11 , MAPK13 , MAP2K1 , MAP2K2 , MAP2K3 , MAP2K6 , RAC1 , RAC2 , RAC3 , RAF1 , RALA , RALB , RALGDS , RAP1A , RAP1B , RAP1GAP , RRAS , MAPK12 , SIPA1 , SRC , TEK , THBS1 , TIAM1 , TLN1 , VASP , VAV2 , VEGFA , VEGFB , VEGFC , FGF23 , PIK3R3 , SKAP1 , FGF18 , FGF17 , FGF16 , F2RL3 , LPAR2 , MAGI1 , BCAR1 , RAPGEF2 , DOCK4 , RAPGEF5 , FARP2 , MAGI2 , FGF19 , AKT3 , RASGRP2 , RAPGEF3 , RGS14 , RAPGEF4 , MRAS , SIPA1L3 , PLCB1 , LPAR3 , PRKD3 , RASGRP3 , PRKD2 , SIPA1L1 , FGF20 , FGF21 , FGF22 , LAT , PARD6A , PLCE1 , ANGPT4 , RAPGEF6 , CALML5 , APBB1IP , PDGFC , PARD3 , LPAR5 , SIPA1L2 , ARAP3 , PDGFD , RASSF5 , TLN2 , PARD6G , PARD6B , CALML4 , CALML6 , ADCY4 , MAGI3 , PFN3 , PFN4 ,