description
The TRP channels that exhibit a unique response to temperature have been given the name thermo-TRPs. Among all thermo- TRP channels, TRPV1-4, TRPM8, and TRPA1 are expressed in subsets of nociceptive dorsal root ganglion (DRG) neuron cell bodies including their peripheral and central projections. These channels can be modulated indirectly by inflammatory mediators such as PGE2, bradykinin, ATP, NGF, and proinflammatory cytokines that are generated during tissue injury. While the noxious heat receptor TRPV1 is sensitized (that is, their excitability can be increased) by post-translational modifications upon activation of G-protein coupled receptors (GPCRs) or tyrosine kinase receptors, the receptors for inflammatory mediators, the same action appears to mainly desensitize TRPM8, the main somatic innocuous cold sensor. This aforementioned sensitization could allow the receptor to become active at body temperature, so it not only contributes toward thermal hypersensitivity but also is possibly a substrate for ongoing persistent pain

external resources
NCBI:948277
KEGG:hsa04750
PUBMED:21841075
PUBMED:15820689
PUBMED:16776582
PUBMED:12838328
PUBMED:17548207
PUBMED:16319926
PUBMED:18427980
PUBMED:20932256
PUBMED:18615141
PUBMED:17124270
PUBMED:17684094
PUBMED:22470230
PUBMED:19074743
PUBMED:23000387
PUBMED:24099085
PUBMED:17321113

genes
ASIC2 , ASIC1 , ADCY1 , ADCY2 , ADCY3 , ADCY5 , ADCY6 , ADCY7 , ADCY8 , ADCY9 , ALOX12 , BDKRB1 , BDKRB2 , CALM1 , CALM2 , CALM3 , CALML3 , CAMK2A , CAMK2B , CAMK2D , CAMK2G , MAPK14 , CYP2J2 , F2RL1 , GNAQ , GNAS , HRH1 , HTR2A , HTR2B , HTR2C , IGF1 , IL1B , IL1R1 , IL1RAP , ITPR1 , ITPR2 , ITPR3 , NGF , NTRK1 , P2RY2 , PIK3CA , PIK3CB , PIK3CD , PIK3R1 , PIK3R2 , PLA2G4A , PLCB2 , PLCB3 , PLCB4 , PLCG1 , PLCG2 , PPP1CA , PPP1CB , PPP1CC , PRKACA , PRKACB , PRKACG , PRKCA , PRKCB , PRKCD , PRKCE , PRKCG , PRKCH , PRKCQ , MAPK8 , MAPK11 , MAPK9 , MAPK10 , MAPK13 , MAP2K3 , MAP2K6 , PTGER2 , PTGER4 , MAPK12 , SRC , TRPV1 , PLA2G6 , PIK3R3 , PLA2G4C , JMJD7-PLA2G4B , TRPA1 , ASIC3 , PLCB1 , TRPV2 , ASIC5 , CALML5 , ASIC4 , TRPV4 , TRPM8 , CALML4 , PLA2G4E , TRPV3 , CALML6 , ADCY4 , PLA2G4F , PLA2G4D , PLA2G4B ,