description
Platelets play a key and beneficial role for primary hemostasis on the disruption of the integrity of vessel wall. Platelet adhesion and activation at sites of vascular wall injury is initiated by adhesion to adhesive macromolecules, such as collagen and von Willebrand factor (vWF), or by soluble platelet agonists, such as ADP, thrombin, and thromboxane A2. Different receptors are stimulated by various agonists, almost converging in increasing intracellular Ca2+ concentration that stimulate platelet shape change and granule secretion and ultimately induce the "inside-out" signaling process leading to activation of the ligand-binding function of integrin alpha IIb beta 3. Binding of alpha IIb beta 3 to its ligands, mainly fibrinogen, mediates platelet adhesion and aggregation and triggers "outside-in" signaling, resulting in platelet spreading, additional granule secretion, stabilization of platelet adhesion and aggregation, and clot retraction

external resources
NCBI:952858
KEGG:hsa04611
PUBMED:20002545
PUBMED:18363565
PUBMED:18544684
PUBMED:18174460
PUBMED:23106920
PUBMED:18550847
PUBMED:22119499
PUBMED:19630797
PUBMED:19286885
PUBMED:17158345
PUBMED:20089227
PUBMED:22701130
PUBMED:21071698
PUBMED:23805129
PUBMED:16149014
PUBMED:18641368

genes
ACTB , ACTG1 , ADCY1 , ADCY2 , ADCY3 , ADCY5 , ADCY6 , ADCY7 , ADCY8 , ADCY9 , AKT1 , AKT2 , RHOA , BTK , COL1A1 , COL1A2 , COL3A1 , MAPK14 , F2R , FCER1G , FCGR2A , FGA , FGB , FGG , FYN , GNAI1 , GNAI2 , GNAI3 , GNAQ , GNAS , GP1BA , GP1BB , GP5 , GP9 , ARHGAP35 , GUCY1A2 , GUCY1A1 , GUCY1B1 , ITGA2 , ITGA2B , ITGB1 , ITGB3 , ITPR1 , ITPR2 , ITPR3 , LCP2 , LYN , MYLK , PPP1R12A , NOS3 , P2RX1 , P2RY1 , PIK3CA , PIK3CB , PIK3CD , PIK3CG , PIK3R1 , PIK3R2 , PLA2G4A , PLCB2 , PLCB3 , PLCB4 , PLCG2 , PPP1CA , PPP1CB , PPP1CC , PRKACA , PRKACB , PRKACG , PRKCI , PRKCZ , PRKG1 , PRKG2 , MAPK1 , MAPK3 , MAPK11 , MAPK13 , PTGIR , PTGS1 , RAP1A , RAP1B , ROCK1 , MAPK12 , SRC , STIM1 , SYK , TBXA2R , TBXAS1 , TLN1 , VASP , VWF , PIK3R3 , PLA2G4C , VAMP8 , JMJD7-PLA2G4B , SNAP23 , F2RL3 , ARHGEF1 , ROCK2 , AKT3 , RASGRP1 , RASGRP2 , MYL12A , GNA13 , PLCB1 , ARHGEF12 , PIK3R5 , GP6 , APBB1IP , P2RY12 , TLN2 , FERMT3 , ORAI1 , MYLK2 , MYLK3 , MYL12B , PLA2G4E , PIK3R6 , ADCY4 , PLA2G4F , PLA2G4D , MYLK4 , PLA2G4B ,