description
Oxytocin (OT) is a nonapeptide synthesized by the magno-cellular neurons located in the supraoptic (SON) and paraventricular (PVN) nuclei of the hypothalamus. It exerts a wide variety of central and peripheral effects. However, its best-known and most well-established roles are stimulation of uterine contractions during parturition and milk release during lactation. Oxytocin also influences cardiovascular regulation and various social behaviors. The actions of OT are all mediated by one type of OT receptor (OTR). This is a transmembrane receptor belonging to the G-protein-coupled receptor superfamily. The main signaling pathway is the Gq/PLC/Ins3 pathway, but the MAPK and the RhoA/Rho kinase pathways are also activated, contributing to increased prostaglandin production and direct contractile effect on myometrial cells. In the cardiovascular system, OTR is associated with the ANP-cGMP and NO-cGMP pathways, which reduce the force and rate of contraction and increase vasodilatation

external resources
NCBI:952859
KEGG:hsa04921
PUBMED:23356278
PUBMED:9219843
PUBMED:20626426
PUBMED:18555543
PUBMED:22190926
PUBMED:21981277
PUBMED:9575824
PUBMED:22227279
PUBMED:19840865
PUBMED:11861513
PUBMED:9326674
PUBMED:12433531
PUBMED:18655881
PUBMED:23335873
PUBMED:22902539
PUBMED:16156781
PUBMED:20141572
PUBMED:14715914
PUBMED:12009385
PUBMED:16787565
PUBMED:16966388

genes
ACTB , ACTG1 , ADCY1 , ADCY2 , ADCY3 , ADCY5 , ADCY6 , ADCY7 , ADCY8 , ADCY9 , RHOA , CCND1 , CACNA1C , CACNA1D , CACNA1F , CACNA1S , CACNA2D1 , CACNB1 , CACNB2 , CACNB3 , CACNB4 , CACNG1 , CALM1 , CALM2 , CALM3 , CALML3 , CAMK4 , CAMK2A , CAMK2B , CAMK2D , CAMK2G , CD38 , CDKN1A , RCAN1 , EEF2 , EGFR , ELK1 , FOS , GNAI1 , GNAI2 , GNAI3 , GNAO1 , GNAQ , GNAS , GUCY1A2 , GUCY1A1 , GUCY1B1 , HRAS , ITPR1 , ITPR2 , ITPR3 , JUN , KCNJ2 , KCNJ3 , KCNJ4 , KCNJ5 , KCNJ6 , KCNJ9 , KCNJ12 , KCNJ14 , KRAS , MEF2C , MYL6 , MYLK , PPP1R12A , PPP1R12B , NFATC1 , NFATC2 , NFATC3 , NFATC4 , NOS3 , NPR1 , NPR2 , NRAS , OXT , OXTR , PIK3CG , PLA2G4A , PLCB2 , PLCB3 , PLCB4 , PPP1CA , PPP1CB , PPP1CC , PPP3CA , PPP3CB , PPP3CC , PPP3R1 , PPP3R2 , PRKAA1 , PRKAA2 , PRKAB1 , PRKAB2 , PRKACA , PRKACB , PRKACG , PRKAG1 , PRKCA , PRKCB , PRKCG , MAPK1 , MAPK3 , MAPK7 , MAP2K1 , MAP2K2 , MAP2K5 , PTGS2 , RAF1 , RGS2 , ROCK1 , RYR1 , RYR2 , RYR3 , SRC , TRPM2 , CAMK1 , PLA2G4C , JMJD7-PLA2G4B , CACNA2D2 , ROCK2 , CACNG3 , CACNG2 , MYL9 , CAMKK2 , PLCB1 , PIK3R5 , CACNG5 , CACNG4 , EEF2K , PRKAG2 , CALML5 , PRKAG3 , PPP1R12C , CACNA2D3 , CAMK1D , CAMK1G , CACNG8 , CACNG7 , CACNG6 , MYLK2 , MYLK3 , CALML4 , CACNA2D4 , PLA2G4E , MYL6B , PIK3R6 , CALML6 , ADCY4 , PLA2G4F , PLA2G4D , MYLK4 , PLA2G4B ,